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Curcuma longa extract protects against 5-fluorouracil-induced oral mucositis in hamsters
Araújo, Aurigena Antunes de; Silva, Edna Maria; Mafra, Cristiane Assunção da Costa Cunha; Costa, Íris do Céu Clara; Barbalho, Amanda Lanna Andrade; Matos, Iolanda Augusta Fernandes de; Santos, Matheus Araujo dos; Lopes, Maria Luiza Diniz de Sousa; Medeiros, Caroline Addison Carvalho Xavier de; Soares, Luiz Alberto Lira; Machado, Janaina Carla Barbosa; Ferreira, Magda Rhayanny Assunção; Araújo, Raimundo Fernandes de; Nascimento, Rubens Maribondo do; Guerra, Gerlane Coelho Bernardo.
Afiliación
  • Araújo, Aurigena Antunes de; Federal University of Rio Grande Norte. Postgraduate Program in Dentistry Science. Natal. BR
  • Silva, Edna Maria; Federal University of Rio Grande Norte. Department of Dentistry. Natal. BR
  • Mafra, Cristiane Assunção da Costa Cunha; Federal University of Rio Grande Norte. Postgraduate Program in Dentistry Science. Natal. BR
  • Costa, Íris do Céu Clara; Federal University of Rio Grande Norte. Department of Dentistry. Natal. BR
  • Barbalho, Amanda Lanna Andrade; Federal University of Rio Grande Norte. Department of Dentistry. Natal. BR
  • Matos, Iolanda Augusta Fernandes de; Federal University of Rio Grande Norte. Department of Dentistry. Natal. BR
  • Santos, Matheus Araujo dos; Federal University of Rio Grande Norte. Department of Dentistry. Natal. BR
  • Lopes, Maria Luiza Diniz de Sousa; Federal University of Rio Grande Norte. Department of Dentistry. Natal. BR
  • Medeiros, Caroline Addison Carvalho Xavier de; Federal University of Rio Grande Norte. Department of Biophysics and Pharmacology. Natal. BR
  • Soares, Luiz Alberto Lira; Federal University of Pernambuco. Department of Pharmaceutical Sciences. Postgraduate Program in Pharmaceutical Science. Recife. BR
  • Machado, Janaina Carla Barbosa; Federal University of Pernambuco. Department of Pharmaceutical Sciences. Postgraduate Program in Pharmaceutical Science. Recife. BR
  • Ferreira, Magda Rhayanny Assunção; Federal University of Pernambuco. Department of Pharmaceutical Sciences. Postgraduate Program in Pharmaceutical Science. Recife. BR
  • Araújo, Raimundo Fernandes de; Federal University of Rio Grande Norte. Postgraduate Program in Functional and Structural Biology. Natal. BR
  • Nascimento, Rubens Maribondo do; Federal University of Rio Grande Norte. Postgraduate Program in Materials Engineer. Natal. BR
  • Guerra, Gerlane Coelho Bernardo; Federal University of Rio Grande Norte. Postgraduate Program in Pharmaceutical Science. Natal. BR
Braz. J. Pharm. Sci. (Online) ; 58: e20114, 2022. tab, graf
Article en En | LILACS | ID: biblio-1403742
Biblioteca responsable: BR40.1
Ubicación: BR40.1
ABSTRACT
Abstract Curcumin, contained at Turmeric (Curcumalonga), can exert many beneficial pleiotropic activities in the gastrointestinal tract. This study evaluated the antioxidant and anti-inflammatory activity of C. longa on 5-fluorouracil (5-FU)-induced oral mucositis (OM) in hamsters. Phytochemical analysis of crude C. longa extract (CLE) was performed to detect the presence of curcumin by TLC and HPLC. Golden Syrian hamsters were orally pre-treated with CLE (5, 50, or 100mg/kg). Cheek pouch samples were subjected to macroscopic and histopathological evaluation. ELISA was performed to quantify the inflammatory cytokines IL-1ß and TNF-α. Superoxide dismutase (SOD), glutathione (GSH) and malondialdehyde (MDA) levels were assessed by ultraviolet-visible spectroscopy analysis. Behavior analysis was conducted by the open field test. Curcumin content in the CLE was 0.55%m/m ± 0.0161 (2.84%). The group treated with 5mg/kg CLE showed healing evidence with macroscopic absence of ulceration (p<0.05) and microscopic aspect of re-epithelialization, discrete inflammatory infiltrate and absence of edema. Treatment with 5mg/kg CLE significantly increased GSH levels, and reduced MDA levels and SOD activity (p˂0.05), and decreased IL-1ß (p˂0.05) and TNF-α (p˂0.01) levels. A significant reduction in walking distance, ambulation, speed, and rearing was observed for motor activity. Curcumin reduced oxidative stress, inflammation, and motor activity in hamsters with 5-FU-induced OM.
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Texto completo: 1 Colección: 01-internacional Base de datos: LILACS Asunto principal: Estomatitis / Curcumina / Curcuma Límite: Animals Idioma: En Revista: Braz. J. Pharm. Sci. (Online) Asunto de la revista: Farmacologia / Terapˆutica / Toxicologia Año: 2022 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Brasil
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Texto completo: 1 Colección: 01-internacional Base de datos: LILACS Asunto principal: Estomatitis / Curcumina / Curcuma Límite: Animals Idioma: En Revista: Braz. J. Pharm. Sci. (Online) Asunto de la revista: Farmacologia / Terapˆutica / Toxicologia Año: 2022 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Brasil