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Epidemiology and risk factors of hypoglycemia in subjects with type 1 diabetes in Brazil: a cross-sectional, multicenter study
Souza, Alexandre Barbosa Câmara de; Correa-Giannella, Maria Lúcia Cardillo; Gomes, Marilia Brito; Negrato, Carlos Antonio; Nery, Marcia.
Afiliación
  • Souza, Alexandre Barbosa Câmara de; Universidade de São Paulo. Faculdade de Medicina. Departamento de Endocrinologia e Metabolismo. São Paulo. BR
  • Correa-Giannella, Maria Lúcia Cardillo; Universidade de São Paulo. Hospital das Clínicas (LIM-18). Laboratório de Carboidratos e Radioimunoensaios. São Paulo. BR
  • Gomes, Marilia Brito; Universidade do Estado do Rio de Janeiro. Unidade de Diabetes. Departamento de Medicina Interna. Rio de Janeiro. BR
  • Negrato, Carlos Antonio; Universidade de São Paulo. Faculdade de Odontologia. Programa de Doutorado em Medicina. Bauru. BR
  • Nery, Marcia; Universidade de São Paulo. Faculdade de Medicina. Departamento de Endocrinologia e Metabolismo. São Paulo. BR
Arch. endocrinol. metab. (Online) ; 66(6): 784-791, Nov.-Dec. 2022. tab, graf
Article en En | LILACS-Express | LILACS | ID: biblio-1403241
Biblioteca responsable: BR1.1
ABSTRACT
ABSTRACT

Objective:

The aim of this study was to investigate the factors associated with hypoglycemia and severe hypoglycemia (SH) in individuals with type 1 diabetes mellitus (T1D) in Brazil. Materials and

methods:

This multicenter, cross-sectional study was conducted between August 2011 and August 2014 across 10 Brazilian cities. The data were obtained from 1,760 individuals with T1D. Sociodemographic and clinical characteristics related to hypoglycemic events in the previous 4 weeks were evaluated.

Results:

Of 1,760 individuals evaluated, 1,319 (74.9%) reported at least one episode of hypoglycemia in the previous 4 weeks. The main factors associated with hypoglycemia were lower hemoglobin A1c (HbA1c) level, better adherence to self-monitoring of blood glucose (SMBG), and higher education level. Episodes of SH were reported by 251 (19%) individuals who, compared with subjects with nonsevere hypoglycemia, received lower doses of prandial insulin and higher doses of basal insulin, in addition to reporting less frequent use of long-acting basal insulin analogs. The percentage of SH episodes was evenly distributed across all ranges of HbA1c levels, and there were no correlations between the mean number of nonsevere or severe hypoglycemic events and HbA1c values. Higher alcohol consumption and more frequent hospitalizations were independently associated with SH.

Conclusion:

Although individuals presenting with hypoglycemia had lower HbA1c values than those not presenting hypoglycemia, there were no correlations between the number of nonsevere hypoglycemia or SH and HbA1c values. Also, the frequency of SH was evenly distributed across all ranges of HbA1c values. Better adherence to SMBG and higher education level were associated with hypoglycemia, while alcohol consumption, higher doses of basal insulin, and more frequent hospitalizations in the previous year were associated with SH.
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Texto completo: 1 Colección: 01-internacional Base de datos: LILACS Tipo de estudio: Clinical_trials / Etiology_studies / Observational_studies / Prevalence_studies / Risk_factors_studies / Screening_studies País/Región como asunto: America do sul / Brasil Idioma: En Revista: Arch. endocrinol. metab. (Online) Asunto de la revista: ENDOCRINOLOGIA / METABOLISMO Año: 2022 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Brasil
Texto completo
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Imprimir
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Texto completo: 1 Colección: 01-internacional Base de datos: LILACS Tipo de estudio: Clinical_trials / Etiology_studies / Observational_studies / Prevalence_studies / Risk_factors_studies / Screening_studies País/Región como asunto: America do sul / Brasil Idioma: En Revista: Arch. endocrinol. metab. (Online) Asunto de la revista: ENDOCRINOLOGIA / METABOLISMO Año: 2022 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Brasil