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Evaluation of the rs35996865 polymorphism of the ROCK1 gene in sepsis
Kale, Aykut; Şener, Elif Funda; Günay, Nahide Ekici; Tahtasakal, Reyhan; Demiryürek, Seniz; Günay, Nurullah; Demiryürek, Abdullah Tuncay.
Afiliación
  • Kale, Aykut; Erciyes University. Faculty of Medicine. Department of Emergency Medicine. Kayseri. TR
  • Şener, Elif Funda; Erciyes University. Faculty of Medicine. Department of Medical Biology. Kayseri. TR
  • Günay, Nahide Ekici; Kayseri City Hospital. Clinics of Medical Biochemistry. Kayseri. TR
  • Tahtasakal, Reyhan; Erciyes University. Faculty of Medicine. Department of Medical Biology. Kayseri. TR
  • Demiryürek, Seniz; Gaziantep University. Faculty of Medicine. Department of Physiology. Gaziantep. TR
  • Günay, Nurullah; Erciyes University. Faculty of Medicine. Department of Emergency Medicine. Kayseri. TR
  • Demiryürek, Abdullah Tuncay; Gaziantep University. Faculty of Medicine. Department of Medical Pharmacology. Gaziantep. TR
Rev. Assoc. Med. Bras. (1992, Impr.) ; Rev. Assoc. Med. Bras. (1992, Impr.);68(5): 586-590, May 2022. tab
Article en En | LILACS-Express | LILACS | ID: biblio-1376178
Biblioteca responsable: BR1.1
ABSTRACT
SUMMARY

OBJECTIVE:

Sepsis is a complex and serious medical condition resulting from the activation of an innate host response to infections. The etiology of sepsis is complex and can be influenced by genetic susceptibility. The purpose of the present study was to investigate a possible association of Rho-kinase 1 (ROCK1) gene polymorphism with sepsis in a Turkish population.

METHODS:

The study group consisted of 100 unrelated patients with sepsis and 100 healthy controls. Genomic DNA was isolated from peripheral leukocytes from EDTA-containing blood using the QIAamp DNA Blood Mini Kit. ROCK1 gene rs35996865 and rs112130712 (Lys1054Arg) polymorphisms were analyzed in genomic DNA using the LightCycler 480 II real-time polymerase chain reaction.

RESULTS:

There were no significant differences in allele and genotype frequencies for ROCK1 gene rs35996865 polymorphism between the patients with sepsis and control group (p>0.05). Additionally, no association was detected between the rs35996865 polymorphism and mortality in the patient group. No polymorphism was detected with ROCK1 gene rs112130712 (Lys1054Arg) in our study groups.

CONCLUSIONS:

Our data showed that there is no marked association between the rs35996865 polymorphism and sepsis. Therefore, these results suggest that ROCK1 gene rs35996865 polymorphism is not risk factor for the development of sepsis in the Turkish population.
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Texto completo: 1 Colección: 01-internacional Base de datos: LILACS Tipo de estudio: Risk_factors_studies Idioma: En Revista: Rev. Assoc. Med. Bras. (1992, Impr.) Asunto de la revista: Educa‡Æo em Sa£de / GestÆo do Conhecimento para a Pesquisa em Sa£de / MEDICINA Año: 2022 Tipo del documento: Article / Project document País de afiliación: Turquía Pais de publicación: Brasil
Texto completo
Añadir a Mi BVS
Imprimir
XML
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: LILACS Tipo de estudio: Risk_factors_studies Idioma: En Revista: Rev. Assoc. Med. Bras. (1992, Impr.) Asunto de la revista: Educa‡Æo em Sa£de / GestÆo do Conhecimento para a Pesquisa em Sa£de / MEDICINA Año: 2022 Tipo del documento: Article / Project document País de afiliación: Turquía Pais de publicación: Brasil