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Pain management & opioid dose reduction with topical sevoflurane instillations in intractable venous ulcers: a case report
Fernández-Ginés, F. Dámaso; Cortiñas-Saenz, Manuel; Agudo-Ponce, Desirée; Morales-Molina, José Antonio; Sánchez, Carmen Fernández; Sierra-Garcia, Francisco.
Afiliación
  • Fernández-Ginés, F. Dámaso; Torrecárdenas University Hospital. Pharmacy Department. Almería. ES
  • Cortiñas-Saenz, Manuel; Torrecárdenas University Hospital. Anesthesiology and Pain Management Department. Almería. ES
  • Agudo-Ponce, Desirée; Torrecárdenas University Hospital. Anesthesiology and Pain Management Department. Almería. ES
  • Morales-Molina, José Antonio; Public Health Agency of Poniente. Pharmacy Department. El ejido. ES
  • Sánchez, Carmen Fernández; Torrecárdenas University Hospital. Pharmacy Department. Almería. ES
  • Sierra-Garcia, Francisco; Torrecárdenas University Hospital. Pharmacy Department. Almería. ES
Braz. J. Pharm. Sci. (Online) ; 58: e18681, 2022. graf
Article en En | LILACS | ID: biblio-1360162
Biblioteca responsable: BR40.1
Ubicación: BR40.1
ABSTRACT
Abstract Vascular ulcers (VU) constitute a major cause of pain and disability, and significantly compromise quality of life. VU have a natural tendency to become chronic and in many cases exhibit anunsatisfactoryresponse to many of the standard therapeutic options.The case of a 73 year-old Caucasian female with severe pain and poorly-controlled pain (Visual Analogic Scale-VAS- of 8-9) due to three lower leg long-standing VUs is reported and discussed herein. The patient was treated with topical instillations of undiluted sevoflurane as per institutional off-label protocol (starting doses of 1mL/cm2 twice a day, and up-titrated according to response to a maximum of 7 mL twice daily). The VAS score dropped to 0-1 shortly after initiation of therapy and remained stable throughout treatment up until the closure of the observations. Subsequently, opioid therapy was gradually tapered down and ultimately abandoned.Sevoflurane application resulted on adequate and sustained pain management of refractory VU, with no significant side effects. On account of its beneficial effectivity and safety profiles, topical sevoflurane emerges as an add-on alternative for the long-term management of VU, and potentially other painful conditions.
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Texto completo: 1 Colección: 01-internacional Base de datos: LILACS Asunto principal: Dolor / Úlcera Varicosa / Informe de Investigación / Sevoflurano / Reducción Gradual de Medicamentos / Analgésicos Opioides Tipo de estudio: Guideline Aspecto: Patient_preference Límite: Aged / Female / Humans Idioma: En Revista: Braz. J. Pharm. Sci. (Online) Asunto de la revista: Farmacologia / Terapˆutica / Toxicologia Año: 2022 Tipo del documento: Article País de afiliación: España Pais de publicación: Brasil
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Texto completo: 1 Colección: 01-internacional Base de datos: LILACS Asunto principal: Dolor / Úlcera Varicosa / Informe de Investigación / Sevoflurano / Reducción Gradual de Medicamentos / Analgésicos Opioides Tipo de estudio: Guideline Aspecto: Patient_preference Límite: Aged / Female / Humans Idioma: En Revista: Braz. J. Pharm. Sci. (Online) Asunto de la revista: Farmacologia / Terapˆutica / Toxicologia Año: 2022 Tipo del documento: Article País de afiliación: España Pais de publicación: Brasil