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Association between visceral/subcutaneous adipose tissue ratio and plasma inflammatory markers and score for cardiovascular risk prediction in a Brazilian cohort: Pró-Saúde Study
Pereira-Manfro, W.F.; Lima, G.R. de; Nogueira Neto, J.F.; Portugal, M.R.C.; Milagres, L.G.; Bezerra, F.F.; Faerstein, E.; Koury, J.C..
Afiliación
  • Pereira-Manfro, W.F.; Universidade do Estado do Rio de Janeiro. Faculdade de Ciências Médicas. Rio de Janeiro. BR
  • Lima, G.R. de; Universidade do Estado do Rio de Janeiro. Faculdade de Ciências Médicas. Rio de Janeiro. BR
  • Nogueira Neto, J.F.; Universidade do Estado do Rio de Janeiro. Faculdade de Ciências Médicas. Rio de Janeiro. BR
  • Portugal, M.R.C.; Universidade do Estado do Rio de Janeiro. Instituto de Nutrição. Rio de Janeiro. BR
  • Milagres, L.G.; Universidade do Estado do Rio de Janeiro. Faculdade de Ciências Médicas. Rio de Janeiro. BR
  • Bezerra, F.F.; Universidade do Estado do Rio de Janeiro. Instituto de Nutrição. Rio de Janeiro. BR
  • Faerstein, E.; Universidade do Estado do Rio de Janeiro. Instituto de Medicina Social. Rio de Janeiro. BR
  • Koury, J.C.; Universidade do Estado do Rio de Janeiro. Instituto de Nutrição. Rio de Janeiro. BR
Braz. j. med. biol. res ; 54(12): e11521, 2021. tab
Article en En | LILACS-Express | LILACS | ID: biblio-1345567
Biblioteca responsable: BR1.1
ABSTRACT
Visceral adipose tissue (VAT) is associated with various metabolic disorders, and adipokines, secreted by adipose tissue, are involved in their pathogenesis. This study investigated associations between VAT/subcutaneous adipose tissue (SAT) ratio, inflammatory markers, and cardiovascular (CV) risk-score in adults. Plasma levels of adipokines, plasma lipid profile, blood pressure, and body composition (using dual-emission x-ray absorptiometry) were determined. CV risk-score based on the American College of Cardiology and the American Heart Association (ACC/AHA) score was calculated in a sample of 309 Brazilian civil servants aged <60 years. Participants' VAT/SAT ratio were categorized into quartiles. Among males, plasma leptin (2.8 ng/mL) and C reactive protein (CRP) (0.2 mg/dL) (P<0.05) levels were higher at P75 and P50 than P5, and the highest calculated CV risk-score was observed at P75 (7.1%). Among females, higher plasma adiponectin levels were observed at P25 (54.3 ng/mL) compared with P75 (36 ng/mL) (P<0.05). Higher plasma CRP levels were observed at P75 (0.4 mg/dL) compared with P5 (0.1 mg/dL) (P<0.05). Higher CV risk-score was observed at P75 (2.0%) compared with P5 (0.7%). In both sexes, VAT and VAT/SAT ratio were directly associated with plasma leptin, CRP, and CV risk-score, and inversely associated with adiponectin; SAT was directly associated with plasma leptin and CRP (P<0.01); interleukin (IL)-10 and CRP were directly associated with adiponectin and leptin, respectively (P<0.05). Among men only, IL-10 (inversely) and CRP (directly) were associated with CV risk-score (P=0.02). Our results strengthened the relevance of the VAT/SAT ratio in cardiovascular risk.
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Texto completo: 1 Colección: 01-internacional Base de datos: LILACS País/Región como asunto: America do sul / Brasil Idioma: En Revista: Braz. j. med. biol. res Asunto de la revista: BIOLOGIA / MEDICINA Año: 2021 Tipo del documento: Article / Project document País de afiliación: Brasil Pais de publicación: Brasil
Texto completo
Añadir a Mi BVS
Imprimir
XML
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Texto completo: 1 Colección: 01-internacional Base de datos: LILACS País/Región como asunto: America do sul / Brasil Idioma: En Revista: Braz. j. med. biol. res Asunto de la revista: BIOLOGIA / MEDICINA Año: 2021 Tipo del documento: Article / Project document País de afiliación: Brasil Pais de publicación: Brasil