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Inflammation and kidney involvement in human viral diseases caused by SARS-CoV-2, HIV, HCV and HBV
Mata, Gustavo Ferreira da; Fernandes, Danilo Euclides; Luciano, Eduardo de Paiva; Sales, Gabriel Teixeira Montezuma; Riguetti, Michelle Tiveron Passos; Kirsztajn, Gianna Mastroianni.
Afiliación
  • Mata, Gustavo Ferreira da; Federal University of São Paulo. Department of Medicine (Nephrology). São Paulo. BR
  • Fernandes, Danilo Euclides; Federal University of São Paulo. Department of Medicine (Nephrology). São Paulo. BR
  • Luciano, Eduardo de Paiva; Federal University of São Paulo. Department of Medicine (Nephrology). São Paulo. BR
  • Sales, Gabriel Teixeira Montezuma; Federal University of São Paulo. Department of Medicine (Nephrology). São Paulo. BR
  • Riguetti, Michelle Tiveron Passos; Federal University of São Paulo. Department of Medicine (Nephrology). São Paulo. BR
  • Kirsztajn, Gianna Mastroianni; Federal University of São Paulo. Department of Medicine (Nephrology). São Paulo. BR
J. venom. anim. toxins incl. trop. dis ; J. venom. anim. toxins incl. trop. dis;27: e20200154, 2021. graf
Article en En | VETINDEX, LILACS | ID: biblio-1287093
Biblioteca responsable: BR68.1
ABSTRACT
Inflammation is closely related to renal diseases. This is particularly true for renal diseases caused by infections as in viral diseases. In this review, we highlight the inflammatory mechanisms that underlie kidney dysfunction in SARS-CoV-2, human immunodeficiency (HIV), hepatitis C (HCV), and hepatitis B (HBV) infections. The pathophysiology of renal involvement in COVID-19 is complex, but kidney damage is frequent, and the prognosis is worse when it happens. Virus-like particles were demonstrated mostly in renal tubular epithelial cells and podocytes, which suggest that SARS-CoV-2 directly affects the kidneys. SARS-CoV-2 uses the angiotensin-converting enzyme 2 receptor, which is found in endothelial cells, to infect the human host cells. Critical patients with SARS-CoV-2-associated acute kidney injury (AKI) show an increase in inflammatory cytokines (IL-1β, IL-8, IFN-γ, TNF-α), known as cytokine storm that favors renal dysfunction by causing intrarenal inflammation, increased vascular permeability, volume depletion, thromboembolic events in microvasculature and persistent local inflammation. Besides AKI, SARS-CoV-2 can also cause glomerular disease, as other viral infections such as in HIV, HBV and HCV. HIV-infected patients present chronic inflammation that can lead to a number of renal diseases. Proinflammatory cytokines and TNF-induced apoptosis are some of the underlying mechanisms that may explain the virus-induced renal diseases that are here reviewed.(AU)
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Texto completo: 1 Colección: 01-internacional Base de datos: LILACS / VETINDEX Asunto principal: Virus de la Hepatitis B / VIH / Hepacivirus / COVID-19 / Glomerulonefritis / Inflamación / Enfermedades Renales Idioma: En Revista: J. venom. anim. toxins incl. trop. dis Asunto de la revista: TOXICOLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Brasil
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: LILACS / VETINDEX Asunto principal: Virus de la Hepatitis B / VIH / Hepacivirus / COVID-19 / Glomerulonefritis / Inflamación / Enfermedades Renales Idioma: En Revista: J. venom. anim. toxins incl. trop. dis Asunto de la revista: TOXICOLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Brasil