Your browser doesn't support javascript.
loading
Reverse vaccinology and subtractive genomics approaches for identifying common therapeutics against Mycobacterium leprae and Mycobacterium lepromatosis
Jaiswal, Arun Kumar; Tiwari, Sandeep; Jamal, Syed Babar; Oliveira, Letícia de Castro; Sales-Campos, Helioswilton; Andrade-Silva, Leonardo Eurípedes; Oliveira, Carlo Jose Freire; Ghosh, Preetam; Barh, Debmalya; Azevedo, Vasco; Soares, Siomar C; Rodrigues Junior, Virmondes; Silva, Marcos Vinicius da.
Afiliación
  • Jaiswal, Arun Kumar; Federal University of Minas Gerais. Institute of Biological Sciences. Belo Horizonte. BR
  • Tiwari, Sandeep; Federal University of Minas Gerais. Institute of Biological Sciences. Belo Horizonte. BR
  • Jamal, Syed Babar; National University of Medical Sciences. Department of Biological Sciences. Rawalpindi. PK
  • Oliveira, Letícia de Castro; Federal University of Minas Gerais. Institute of Biological Sciences. Belo Horizonte. BR
  • Sales-Campos, Helioswilton; Federal University of Triângulo Mineiro. Institute of Biological Sciences and Natural Sciences. Department of Immunology, Microbiology and Parasitology. Uberaba. BR
  • Andrade-Silva, Leonardo Eurípedes; Federal University of Triângulo Mineiro. Institute of Health Sciences. Infectious Disease Department. Uberaba. BR
  • Oliveira, Carlo Jose Freire; Federal University of Triângulo Mineiro. Institute of Biological Sciences and Natural Sciences. Department of Immunology, Microbiology and Parasitology. Uberaba. BR
  • Ghosh, Preetam; Virginia Commonwealth University. Department of Computer Science. Richmond. US
  • Barh, Debmalya; Institute of Integrative Omics and Applied Biotechnology. Centre for Genomics and Applied Gene Technology. Nonakuri. IN
  • Azevedo, Vasco; Federal University of Minas Gerais. Institute of Biological Sciences. Belo Horizonte. BR
  • Soares, Siomar C; Federal University of Triângulo Mineiro. Institute of Biological Sciences and Natural Sciences. Department of Immunology, Microbiology and Parasitology. Uberaba. BR
  • Rodrigues Junior, Virmondes; Federal University of Triângulo Mineiro. Institute of Biological Sciences and Natural Sciences. Department of Immunology, Microbiology and Parasitology. Uberaba. BR
  • Silva, Marcos Vinicius da; Federal University of Triângulo Mineiro. Institute of Biological Sciences and Natural Sciences. Department of Immunology, Microbiology and Parasitology. Uberaba. BR
J. venom. anim. toxins incl. trop. dis ; J. venom. anim. toxins incl. trop. dis;27: e20200027, 2021. tab, graf
Article en En | VETINDEX, LILACS | ID: biblio-1287091
Biblioteca responsable: BR68.1
ABSTRACT
Mycobacterium leprae and Mycobacterium lepromatosis are gram-positive bacterial pathogens and the causative agents of leprosy in humans across the world. The elimination of leprosy cannot be achieved by multidrug therapy alone, and highlights the need for new tools and drugs to prevent the emergence of new resistant strains. Methods In this study, our contribution includes the prediction of vaccine targets and new putative drugs against leprosy, using reverse vaccinology and subtractive genomics. Six strains of Mycobacterium leprae and Mycobacterium lepromatosis (4 and 2 strains, respectively) were used for comparison taking Mycobacterium leprae strain TN as the reference genome. Briefly, we used a combined reverse vaccinology and subtractive genomics approach. Results As a result, we identified 12 common putative antigenic proteins as vaccine targets and three common drug targets against Mycobacterium leprae and Mycobacterium lepromatosis. Furthermore, the docking analysis using 28 natural compounds with three drug targets was done. Conclusions The bis-naphthoquinone compound Diospyrin (CID 308140) obtained from indigenous plant Diospyros spp. showed the most favored binding affinity against predicted drug targets, which can be a candidate therapeutic target in the future against leprosy.(AU)
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: LILACS / VETINDEX Asunto principal: Bacilos Grampositivos / Vacunología / Mycobacterium leprae / Mycobacterium lepraemurium Idioma: En Revista: J. venom. anim. toxins incl. trop. dis Asunto de la revista: TOXICOLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Brasil / India / Pakistán / Estados Unidos Pais de publicación: Brasil
Texto completo
Añadir a Mi BVS
Imprimir
XML
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: LILACS / VETINDEX Asunto principal: Bacilos Grampositivos / Vacunología / Mycobacterium leprae / Mycobacterium lepraemurium Idioma: En Revista: J. venom. anim. toxins incl. trop. dis Asunto de la revista: TOXICOLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Brasil / India / Pakistán / Estados Unidos Pais de publicación: Brasil