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Platelet-concentrated and platelet poor-plasma promote different pattern on immunohistochemical expression of TGF-β1, however they impairs the osteoneogensis in calvarial defects treated with autograft due suppression of osteocalcin
Oliveira-Filho, Marco Antonio de; Souza, Marcelo; Tabushi, Fernando Issamu; Almeida, Luís Eduardo; Figueiredo, Fernanda Pirajá; Lourenço, Elora Sampaio; Giovanini, Allan Fernando; Malafaia, Osvaldo; Ribas Filho, Jurandir Marcondes.
Afiliación
  • Oliveira-Filho, Marco Antonio de; Hospital Universitário Evangélico Mackenzie. Medical Research Institute. Curitiba. BR
  • Souza, Marcelo; Hospital Universitário Evangélico Mackenzie. Medical Research Institute. Curitiba. BR
  • Tabushi, Fernando Issamu; Hospital Universitário Evangélico Mackenzie. Medical Research Institute. Curitiba. BR
  • Almeida, Luís Eduardo; Marquette University. US
  • Figueiredo, Fernanda Pirajá; Hospital Universitário Evangélico Mackenzie. Curitiba. BR
  • Lourenço, Elora Sampaio; Hospital Universitário Evangélico Mackenzie. Curitiba. BR
  • Giovanini, Allan Fernando; Hospital Universitário Evangélico Mackenzie. Medical Research Institute. Curitiba. BR
  • Malafaia, Osvaldo; Hospital Universitário Evangélico Mackenzie. Medical Research Institute. Curitiba. BR
  • Ribas Filho, Jurandir Marcondes; Hospital Universitário Evangélico Mackenzie. Medical Research Institute. Curitiba. BR
Acta cir. bras ; 36(6): e360604, 2021. tab, graf
Article en En | LILACS, VETINDEX | ID: biblio-1284910
Biblioteca responsable: BR1.1
ABSTRACT
ABSTRACT Purpose Herein we evaluated the effects of platelet concentrate (PC) and platelet-poor plasma (PPP) on bone repair using noncritical defects in the calvaria of rabbits and compared them to the presence of TGF-β1 and osteocalcin on reparative sites. Methods Five noncritical defects of 8.7 mm in diameter were created on the calvaria of 15 animals. Each defect was treated differently, using autograft (ABG), ABG associated with PC (ABG + PC), ABG with PPP (ABG + PPP), isolated PPP, and blood clot (control). The animals were submitted to euthanasia on the second, fourth and sixth week post-surgery. Results The defects that received ABG+PC or PPP demonstrated lower bone formation when compared to specimens that received ABG in the same period. These results coincided to significant higher immunopositivity for TGF-β1 for specimens that received PC, and lower presence of cytokine in the group PPP. However, either higher or lower presence of TGF-β1 were also correlated to lower presence of osteocalcin. Likewise, these results were similar to findings in specimens treated only with PPP when compared to control. Conclusions PC and PPP were not effective when applied in association with ABG. Similarly, isolated use of PPP was not beneficial in optimizing the bone repair.
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Texto completo: 1 Colección: 01-internacional Base de datos: LILACS / VETINDEX Asunto principal: Osteogénesis / Factor de Crecimiento Transformador beta1 Límite: Animals Idioma: En Revista: Acta cir. bras Asunto de la revista: CIRURGIA GERAL / Procedimentos Cir£rgicos Operat¢rios Año: 2021 Tipo del documento: Article País de afiliación: Brasil / Estados Unidos Pais de publicación: Brasil
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: LILACS / VETINDEX Asunto principal: Osteogénesis / Factor de Crecimiento Transformador beta1 Límite: Animals Idioma: En Revista: Acta cir. bras Asunto de la revista: CIRURGIA GERAL / Procedimentos Cir£rgicos Operat¢rios Año: 2021 Tipo del documento: Article País de afiliación: Brasil / Estados Unidos Pais de publicación: Brasil