Studies on the lepromin test. III. Influence of tuberculosis contact and other factors on the size of the lepromin reaction
Int. j. lepr
; 29(4): 488-495, Oct.-Dec. 1961. tab, graf
Article
en En
| SES-SP, HANSEN, HANSENIASE, SESSP-ILSLACERVO, SES-SP
| ID: biblio-1227986
Biblioteca responsable:
BR191.1
Ubicación: [{"text": "BR191.1"}]
ABSTRACT
In performing the tuberculin test, especially in countries with a high prevalence of nonspecific tuberculin reactions, several technical factors are of great importance with respect to accuracy of the results. In every country or area the border between specific and nonspecific reactions must be defined before drawing conclusions about the relation between tuberculin and lepromin reactions. If this is done properly it is evident that the effect of infection with M. tuberculosis on the size of the lepromin reactions is important. It is not permitted to draw conclusions about resistance to leprosy from a negative lepromin reaction, when the tuberculin reaction is not known. The size of the lepromin reaction is limited by young age. Besides M. leprae and M. tuberculosis, other acid-fast bacilli have an influence on the size of the lepromin reaction, but the influence is slower and weaker. The hypothesis of Rotberg that an endogenous factor ("N factor") is necessary to enable an individual to develop resistance to M. leprae would explain much about the epidemiology of leprosy, if this factor is a quantitative and hereditary one. In addition to this factor one has to assume one or more local tissue factor to explain such clinical findings as the "immune area" (Wade). Theoretically it is improbable that tuberculosis contact or BCG vaccination has any effect on the N factor. In practice, however, evidence was found that previous tuberculosis cntact gives some protection against leprosy in part of the population, probably only in those people who possess the endogenous factor which enables them to develop some degree of immunity.
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Colección:
06-national
/
BR
Base de datos:
HANSEN
/
HANSENIASE
/
SES-SP
/
SESSP-ILSLACERVO
Asunto principal:
Lepromina
/
Lepra
Tipo de estudio:
Risk_factors_studies
Idioma:
En
Revista:
Int. j. lepr
Año:
1961
Tipo del documento:
Article