Effect of BCG vaccination, lepromin testing and natural causes in inducing reactivity to lepromin and to tuberculin
Int. j. lepr
; 25(1): 13-37, Jan.-Mar. 1957. tab, graf
Article
en En
| SES-SP, HANSEN, HANSENIASE, SESSP-ILSLACERVO, SES-SP
| ID: biblio-1227739
Biblioteca responsable:
BR191.1
Ubicación: [{"text": "BR191.1"}]
ABSTRACT
1- A report is made of an effort to determine the relative importance of natural causes, initial lepromin testing, and vaccination with BCG in producing reactivity to lepromin and to tuberculin. The possibility is admitted that the final lepromin test may itself cause reactivity of the Mitsuda type but there is no available means of separating this efffect from that of natural causes. 2- The subjects were 550 apparently healthy children, 6 months to 35 months of age, having no known contact with leprosy, living in their homes on Mactan Island, Cebu, Philippines, of whom 483 completed all requirements of the study. 3- A random sample of one-fifth constituted a basic control group, given initially only a tuberculin test (PPD-S, 0.0001 mgm.). The remainder were tested with lepromin and PPD-S, and those negative to both were divided at random into four subgroups. Two were vaccinated intradermally with BCG, one with a fresh preparation and the other with a lyophilized one. The other subgroups were given diphtheria toxoid and saline, respectively. Ninety to 100 days after the BCG and other inoculations, and, on the average, 143 days after the initial tests, all children including the basic controls were tested with lepromin and PPD-S of the same lots, and in the same dosages, as those used at the outset...
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Colección:
06-national
/
BR
Base de datos:
HANSEN
/
HANSENIASE
/
SES-SP
/
SESSP-ILSLACERVO
Asunto principal:
Lepromina
/
Lepra
Tipo de estudio:
Etiology_studies
Idioma:
En
Revista:
Int. j. lepr
Año:
1957
Tipo del documento:
Article