Quality by Design-driven investigation of the mechanical properties of mucoadhesive films for needleless anesthetics administration
Rev. ciênc. farm. básica apl
; 42: 1-12, 20210101.
Article
en En
|
LILACS-Express
| LILACS
| ID: biblio-1177729
Biblioteca responsable:
BR1851.9
ABSTRACT
Objectives:
To systematically evaluate the effects of hydroxypropyl methyl cellulose (HPMC) type (E5LV, E15LV, and K100LV); plasticizer type (glycerol and mannitol), plasticizer loading (0.12 and 0.24% w/w); and loading of prilocaine and lidocaine hydrochlorides combined at 11 ratio (0 and 47 mg/cm2) in the mechanical properties of buccal films.Methods:
A quality by design (QbD) approach based on a full factorial design (3 x 23) and complementarily multivariate statistical tools i.e., principal component analysis (PCA), response surface methodology (RSM), and correlation matrix were used in this pursuit. The thickness, elongation at break, tensile strength, force at break, and Young`s modulus of the anesthetic buccal films obtained by solvent casting were assessed.Results:
The QbD, PCA and RSM altogether demonstrated that all studied formulation variables, mainly the drug loading, affect the mechanical properties of the films at different significance levels. The multivariate analysis yielded the modelling of elongation at break, tensile strength, and force at break, which significantly correlated with each other. The drugs exerted a synergic plasticizing effect on the films, and the use of HPMC K100 LV (with greater hydroxypropyl substitution degree and viscosity) and mannitol favored their elasticity and resistance. Furthermore, the majority of the films fulfilled the requirements for buccal administration due to their softness and mechanical resistance.Conclusion:
Mannitol is suitable plasticizer for manufacturing HPMC anesthetic buccal films with improved mechanical properties. These results are a step forward in the rational development of formulations for the replacement of needles in dentistry
Texto completo:
1
Colección:
01-internacional
Base de datos:
LILACS
Tipo de estudio:
Prognostic_studies
Idioma:
En
Revista:
Rev. ciênc. farm. básica apl
Asunto de la revista:
FARMACOLOGIA
Año:
2021
Tipo del documento:
Article
País de afiliación:
Brasil
Pais de publicación:
Brasil