Low and high molecular weight chitosans interactions with Streptococcus mutans: an in vitro study
Acta odontol. latinoam
; 16(1-2): 9-16, 2003.
Article
en Es
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LILACS-Express
| LILACS, BINACIS
| ID: biblio-1157654
Biblioteca responsable:
AR29.1
Ubicación: [{"text": "AR29.1"}]
ABSTRACT
We evaluated the in vitro capacity of high and low molecular weight chitosans (HMWCh and LMWCh) to inhibit the adherence of strains of S. mutans obtained from the American Type Culture Collection (ATCC,25175) to artificial saliva-coated hydroxiapatite beads. The effect of these biopolymers was assessed in terms of pH, ionic force, minimum inhibitory concentration (MIC) and antibacterial activity. The results show that HMWCh is modified by a rise in pH (7.0) and ionic strength. The induced conformational changes lead to the formation of rigid meshes capable of aggregating and entrapping S. mutans. This process is associated to the properties of HMWCh. LMWCh gave rise to smaller aggregates that exhibited a comparatively reduced interaction capacity. The MIC for HMWCh was 0.5 g
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Colección:
01-internacional
Base de datos:
BINACIS
/
LILACS
Idioma:
Es
Revista:
Acta odontol. latinoam
Asunto de la revista:
ODONTOLOGIA
Año:
2003
Tipo del documento:
Article
Pais de publicación:
Argentina