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Metabolomics as a potential tool for the diagnosis of growth hormone deficiency (GHD): a review
San-Martin, Breno Sena De; Ferreira, Vinícius Guimarães; Disciplina de EndocrinologiaBitencourt, Mariana Rechia; Disciplina de EndocrinologiaPereira, Paulo Cesar Gonçalves; Carrilho, Emanuel; Assunção, Nilson Antônio de; Departamento de QuímicaCarvalho, Luciani Renata Silveira de.
Afiliación
  • San-Martin, Breno Sena De; Universidade Federal de São Paulo. Escola Paulista de Medicina. São Paulo. BR
  • Ferreira, Vinícius Guimarães; Universidade de São Paulo. Instituto de Química de São Carlos. São Carlos. BR
  • Disciplina de EndocrinologiaBitencourt, Mariana Rechia; Universidade de São Paulo. Faculdade de Medicina. Disciplina de EndocrinologiaBitencourt, Mariana Rechia. São Paulo. BR
  • Disciplina de EndocrinologiaPereira, Paulo Cesar Gonçalves; Universidade de São Paulo. Faculdade de Medicina. Disciplina de EndocrinologiaPereira, Paulo Cesar Gonçalves. São Paulo. BR
  • Carrilho, Emanuel; Universidade de São Paulo. Instituto de Química de São Carlos. São Carlos. BR
  • Assunção, Nilson Antônio de; Universidade Federal de São Paulo. Escola Paulista de Medicina. São Paulo. BR
  • Departamento de QuímicaCarvalho, Luciani Renata Silveira de; Universidade Federal de São Paulo. Instituto de Ciências Ambientais, Químicas e Farmacêuticas. Departamento de QuímicaCarvalho, Luciani Renata Silveira de. Diadema. BR
Arch. endocrinol. metab. (Online) ; 64(6): 654-663, Nov.-Dec. 2020. tab, graf
Article en En | LILACS | ID: biblio-1142210
Biblioteca responsable: BR1.1
ABSTRACT
ABSTRACT Metabolomics uses several analytical tools to identify the chemical diversity of metabolites present in organisms. These metabolites are low molecular weight molecules (<1500 Da) classified as a final or intermediary product of metabolic processes. The application of this omics technology has become prominent in inferring physiological conditions through reporting on the phenotypic state; therefore, the introduction of metabolomics into clinical studies has been growing in recent years due to its efficiency in discriminating pathophysiological states. Regarding endocrine diseases, there is a great interest in verifying comprehensive and individualized physiological scenarios, in particular for growth hormone deficiency (GHD). The current GHD diagnostic tests are laborious and invasive and there is no exam with ideal reproducibility and sensitivity for diagnosis neither standard GH cut-off point. Therefore, this review was focussed on articles that applied metabolomics in the search for new biomarkers for GHD. The present work shows that the applications of metabolomics in GHD are still limited, since the little complementarily of analytical techniques, a low number of samples, GHD combined to other deficiencies, and idiopathic diagnosis shows a lack of progress. The results of the research are relevant and similar; however, their results do not provide an application for clinical practice due to the lack of multidisciplinary actions that would be needed to mediate the translation of the knowledge produced in the laboratory, if transferred to the medical setting.
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Texto completo: 1 Colección: 01-internacional Base de datos: LILACS Asunto principal: Hormona de Crecimiento Humana / Enanismo Hipofisario / Metabolómica Tipo de estudio: Diagnostic_studies Límite: Humans Idioma: En Revista: Arch. endocrinol. metab. (Online) Asunto de la revista: ENDOCRINOLOGIA / METABOLISMO Año: 2020 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Brasil
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Texto completo: 1 Colección: 01-internacional Base de datos: LILACS Asunto principal: Hormona de Crecimiento Humana / Enanismo Hipofisario / Metabolómica Tipo de estudio: Diagnostic_studies Límite: Humans Idioma: En Revista: Arch. endocrinol. metab. (Online) Asunto de la revista: ENDOCRINOLOGIA / METABOLISMO Año: 2020 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Brasil