Long-term positive severe acute respiratory syndrome coronavirus 2 ribonucleic acid and therapeutic effect of antivirals in patients with coronavirus disease: Case reports
Rev. Soc. Bras. Med. Trop
; 53: e20200372, 2020. graf
Article
en En
| SES-SP, ColecionaSUS, LILACS
| ID: biblio-1136859
Biblioteca responsable:
BR1.1
ABSTRACT
Abstract Coronavirus disease (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been declared a pandemic. We herein report four COVID-19 cases with long-term positive viral ribonucleic acid (RNA) for about 61 days. Despite treatment with recombinant human interferon, convalescent plasma from COVID-19 patients, arbidol, etc., nucleic acid results were still positive for SARS-CoV-2. After treatment with ritonavir-boosted danoprevir (DNVr, 100/100 mg, once daily), all four patients showed two to three consecutive negative SARS-CoV-2 RNA and were thus discharged from hospital. Therefore, DNVr may be a potentially effective antiviral for COVID-19 patients with long-term positive SARS-CoV-2 RNA.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
LILACS
/
SES-SP
/
ColecionaSUS
Asunto principal:
ARN Viral
/
Infecciones por Coronavirus
Límite:
Adult
/
Aged
/
Humans
/
Male
Idioma:
En
Revista:
Rev. Soc. Bras. Med. Trop
Asunto de la revista:
MEDICINA TROPICAL
Año:
2020
Tipo del documento:
Article
País de afiliación:
China
Pais de publicación:
Brasil