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Evaluation of Polymorphisms in IL8 and IL16 Genes in Patients with Acute Coronary Syndrome
Silva, Lílian Caroliny Amorim; Araújo, Romário Martins; Soares, Fábia Carla Silva; Werkhauser, Roberto Pereira; Montenegro, Sergio Tavares; Tashiro, Tetsuo; Carvalho, Viviane do Carmo Vasconcelos; Montenegro, Silvia Maria Lucena.
Afiliación
  • Silva, Lílian Caroliny Amorim; Instituto Aggeu Magalhães. Recife. BR
  • Araújo, Romário Martins; Instituto Aggeu Magalhães. Recife. BR
  • Soares, Fábia Carla Silva; Instituto Aggeu Magalhães. Recife. BR
  • Werkhauser, Roberto Pereira; Instituto Aggeu Magalhães. Recife. BR
  • Montenegro, Sergio Tavares; Real Hospital Português de Beneficência em Pernambuco. Recife. BR
  • Tashiro, Tetsuo; Universidade Federal de Pernambuco. Recife. BR
  • Carvalho, Viviane do Carmo Vasconcelos; Instituto Aggeu Magalhães. Recife. BR
  • Montenegro, Silvia Maria Lucena; Instituto Aggeu Magalhães. Recife. BR
Int. j. cardiovasc. sci. (Impr.) ; 33(3): 254-262, May-June 2020. tab, graf
Article en En | LILACS | ID: biblio-1134359
Biblioteca responsable: BR1.1
ABSTRACT
Abstract

Background:

Acute coronary syndrome (ACS) is a cardiovascular disease caused by obstruction of coronary arteries by atheromatous plaque. Susceptibility to this disease may be related to genetic variations, such as single nucleotide polymorphisms (SNPs).

Objective:

In this study, we evaluated the relationship between SNPs in IL8 (rs4073; -251 A/T) and IL16 (rs11556218; T/G) genes and SCA in a Brazilian population. Materials and

Methods:

A sample of 200 patients with ACS and 50 non-ACS patients hospitalized at the Real Hospital Português, Recife - PE, Brazil, and 220 blood donors (donors) was used. Genotyping was carried out by polymerase chain reaction, and DNA sequencing. Statistical analyzes were performed using the Williams G, Chi-square and Kruskal Wallis tests, using the BioEstat 5.0 program, and the data with a value of p < 0.05 were considered significant.

Results:

In the IL8 gene, the AT genotype was the most frequent (p > 0.05) in all three groups. In the IL16 gene, genotypic distributions were different between patients with ACS and the donor group (p = 0.002), with the most frequent G allele in the second group (p = 0.0052). The IL-16 cytokine was higher in donors than in patients with ACS (p = 0.04) and the G (TG + GG) allele had higher values of this cytokine (p = 0.01).

Conclusions:

The results demonstrate the important role of the rs11556218 SNP in IL16 gene in SCA, evidencing that the G allele may be associated with a decreased risk of the disease.
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Texto completo: 1 Colección: 01-internacional Base de datos: LILACS Asunto principal: Polimorfismo de Nucleótido Simple / Síndrome Coronario Agudo / Genotipo Límite: Adult / Aged / Female / Humans / Male Idioma: En Revista: Int. j. cardiovasc. sci. (Impr.) Asunto de la revista: CARDIOLOGIA Año: 2020 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Brasil
Texto completo
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Imprimir
XML
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Texto completo: 1 Colección: 01-internacional Base de datos: LILACS Asunto principal: Polimorfismo de Nucleótido Simple / Síndrome Coronario Agudo / Genotipo Límite: Adult / Aged / Female / Humans / Male Idioma: En Revista: Int. j. cardiovasc. sci. (Impr.) Asunto de la revista: CARDIOLOGIA Año: 2020 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Brasil