The roles of miRNA, lncRNA and circRNA in the development of osteoporosis

Yang, Yang; Yujiao, Wang; Fang, Wang; Linhui, Yuan; Ziqi, Guo; Zhichen, Wei; Zirui, Wang; Shengwang, Wang

Yang, Yang; Yujiao, Wang; Fang, Wang; Linhui, Yuan; Ziqi, Guo; Zhichen, Wei; Zirui, Wang; Shengwang, Wang.

Afiliación

Yang, Yang; Sichuan University. West China Hospital. Department of Medical Oncology. Chengdu. CN
Yujiao, Wang; Second Clinical Medical College of Lanzhou University. Lanzhou. CN
Fang, Wang; Peoples Hospital of Guazhou County. CN
Linhui, Yuan; Second Clinical Medical College of Lanzhou University. Lanzhou. CN
Ziqi, Guo; Second Clinical Medical College of Lanzhou University. Lanzhou. CN
Zhichen, Wei; Second Clinical Medical College of Lanzhou University. Lanzhou. CN
Zirui, Wang; Second Clinical Medical College of Lanzhou University. Lanzhou. CN
Shengwang, Wang; Peoples Hospital of Guazhou County. CN

Biol. Res ; 53: 40, 2020. tab, graf

Article en En | LILACS | ID: biblio-1131891

Biblioteca responsable: CL1.1

ABSTRACT

ABSTRACT

Osteoporosis is a common metabolic bone disease, influenced by genetic and environmental factors, that increases bone fragility and fracture risk and, therefore, has a serious adverse effect on the quality of life of patients. However, epigenetic mechanisms involved in the development of osteoporosis remain unclear. There is accumulating evidence that epigenetic modifications may represent mechanisms underlying the links of genetic and environmental factors with increased risk of osteoporosis and bone fracture. Some RNAs, such as microRNAs (miRNAs), long noncoding RNAs (lncRNAs), and circular RNAs (circRNAs), have been shown to be epigenetic regulators with significant involvement in the control of gene expression, affecting multiple biological processes, including bone metabolism. This review summarizes the results of recent studies on the mechanisms of miRNA-, lncRNA-, and circRNA-mediated osteoporosis associated with osteoblasts and osteoclasts. Deeper insights into the roles of these three classes of RNA in osteoporosis could provide unique opportunities for developing novel diagnostic and therapeutic approaches to this disease.

Asunto(s)

Humanos; Osteoporosis/genética; MicroARNs/genética; ARN Largo no Codificante/genética; ARN Circular/genética

Palabras clave

CircRNA; Lncrna; MiRNA; Osteoporosis

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Texto completo: 1 Colección: 01-internacional Base de datos: LILACS Asunto principal: Osteoporosis / MicroARNs / ARN Largo no Codificante / ARN Circular Aspecto: Patient_preference Límite: Humans Idioma: En Revista: Biol. Res Asunto de la revista: BIOLOGIA Año: 2020 Tipo del documento: Article País de afiliación: China Pais de publicación: Chile

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