Modelo de indução de osteoporose em coelhas - avaliação radiográfica / Rabbit osteoporosis induction model - radiographic evaluation
Arq. bras. med. vet. zootec. (Online)
; 72(2): 633-636, Mar./Apr. 2020. ilus, graf
Article
en Pt
| LILACS, VETINDEX
| ID: biblio-1128494
Biblioteca responsable:
BR68.1
ABSTRACT
In order to establish a bone loss induction model in rabbits to study osteoporosis, 18 rabbits underwent ovariectomy and received methylprednisolone 1mg/kg intramuscularly on alternate days for two weeks. Immediately before ovariectomy up to 42 days after methylprednisolone administration, radiographs of the right olecranon were taken in the mediolateral position to evaluate the radiographic optical density. Before the induction of osteoporosis, rabbits presented mean values of radiographic density of 2.305mm Al and at 42 days of 1.575mm Al. The values obtained were submitted to ANOVA for repeated measures that revealed a significant drop (P< 0.001) in the density over time, proving that the induction was able to trigger bone loss of these animals. With this, it can be affirmed that the adopted protocol was enough to provoke a significant bone loss, characterizing a valid model for the study of new treatments for osteoporosis.(AU)
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
LILACS
/
VETINDEX
Asunto principal:
Osteoporosis
/
Regeneración Ósea
/
Densidad Ósea
Tipo de estudio:
Guideline
Límite:
Animals
Idioma:
Pt
Revista:
Arq. bras. med. vet. zootec. (Online)
Asunto de la revista:
Medicina Veterin ria
Año:
2020
Tipo del documento:
Article
País de afiliación:
Brasil
Pais de publicación:
Brasil