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Effects of moderate aerobic exercise on thoracic aortic remodeling of female LDL-receptor knockout ovariectomized mice
Lima, Nathalia Edviges Alves de; Brianezi, Ledimar; Nucci, Ricardo Aparecido Baptista; Cardoso, Clever Gomes; Magalhães, Walkyria Villegas; Chucata, Kemily Loren Barros; Fonseca, Fernando Luiz Afonso; Maifrino, Laura Beatriz Mesiano.
Afiliación
  • Lima, Nathalia Edviges Alves de; São Judas Tadeu University. São Paulo. BR
  • Brianezi, Ledimar; São Judas Tadeu University. São Paulo. BR
  • Nucci, Ricardo Aparecido Baptista; University of São Paulo Medical School. São Judas Tadeu University. São Paulo. BR
  • Cardoso, Clever Gomes; Federal University of Goiás. Goiânia. BR
  • Magalhães, Walkyria Villegas; São Judas Tadeu University. São Paulo. BR
  • Chucata, Kemily Loren Barros; São Judas Tadeu University. São Paulo. BR
  • Fonseca, Fernando Luiz Afonso; Federal University of São Paulo (UNIFESP). São Paulo. BR
  • Maifrino, Laura Beatriz Mesiano; Dante Pazzanese Institute of Cardiology. São Paulo. BR
Acta histochem. (Print) ; 122(5): 151575-151575, Jul. 2020. ilus., tab.
Article en En | SES-SP, SESSP-IDPCPROD, SES-SP | ID: biblio-1123155
Biblioteca responsable: BR79.1
Ubicación: BR79.1
ABSTRACT
Menopause is a major factor involved in dyslipidemia increasing the risk of atherosclerosis which may be reversed by a routine of aerobic physical activity. Thus, this study aimed to analyze the effects of aerobic training on the thoracic aorta of female LDL-receptor knockout mice submitted to estrogen deprivation. Fifteen genetically modified female mice, knockout for the low-density lipoprotein receptor (LDL-Knockout group) were used as experimental groups and fifteen wild female mice (C57BL/6 J) were used as control groups. Animals were divided as (n = 5/per group) sedentary control (SC); sedentary control ovariectomized (SCO); trained control ovariectomized (TCO); LDL-Knockout sedentary (KS); LDL-Knockout sedentary ovariectomized (KOS); and LDL-Knockout trained ovariectomized (KOT). Immunohistochemical techniques for TIMP-1 and metalloproteinases 2 and 9 were used to evaluate thoracic aorta remodeling. Picrosirius stain was used to highlight the collagen fibers. Verhoff-Van Gienson was used for the quantitative analyses of elastic lamellae. Our results demonstrate a positive remodeling promoted by physical exercise in ovariectomized and dyslipidemic animals. However, further studies are needed including the evaluation of inflammatory markers present in dyslipidemia.
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Colección: 06-national / BR Base de datos: SES-SP / SESSP-IDPCPROD Asunto principal: Aorta / Menopausia / Ejercicio Físico Idioma: En Revista: Acta histochem. (Print) Año: 2020 Tipo del documento: Article
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Colección: 06-national / BR Base de datos: SES-SP / SESSP-IDPCPROD Asunto principal: Aorta / Menopausia / Ejercicio Físico Idioma: En Revista: Acta histochem. (Print) Año: 2020 Tipo del documento: Article