DNA damage in BALB/c mice infected with Lacazia loboi and its relation to nutritional status
Botucatu; s.n; 2015. 5 p. tab.
Non-conventional
en En
| SES-SP, SESSP-ILSLPROD, SES-SP, SESSP-ILSLACERVO, SES-SP
| ID: biblio-1085422
Biblioteca responsable:
BR191.1
Ubicación: BR191.1; 9474/s
ABSTRACT
Background:
Jorge Lobos disease, also known as lacaziosis, is a cutaneous-subcutaneous mycosis with chronic evolution. It is caused by the fungus Lacazia loboi. Herein we report a study that relates the genotoxicity caused by L. loboi in isogenic mice with nutritional status, through a normal or restricted diet.Methods:
DNA damage was assessed in the peripheral blood by the comet assay (tail intensity).Results:
The results for leukocytes showed increases in the mean tail intensity in mice under dietary restriction, in infected mice under dietary restriction and in infected mice ingesting a normal diet.Conclusion:
These results indicate that dietary restriction and L. loboi infection may increase DNA damage levels in mice, as detected by the comet assayPalabras clave
Texto completo:
1
Colección:
06-national
/
BR
Base de datos:
SES-SP
/
SESSP-ILSLACERVO
/
SESSP-ILSLPROD
Asunto principal:
Ensayo Cometa
/
Desnutrición
/
Genotoxicidad
/
Lacazia
/
Lobomicosis
Aspecto:
Determinantes_sociais_saude
Límite:
Animals
Idioma:
En
Año:
2015
Tipo del documento:
Non-conventional
Pais de publicación:
Brasil