Your browser doesn't support javascript.
loading
Pleiotropic Effects With Equivalent Low-density Lipoprotein Cholesterol Reduction: Comparative Study Pleiotropic Effects With Equivalent Low-density
Araujo, Daniel B; Bertolami, Marcelo C; Ferreira, Waldinai P; Abdalla, Dulcineia SP; Faludi, Andre A; Nakamura, Yara; Bricharello, Liliana P.
Afiliación
  • Araujo, Daniel B; Instituto Dante Pazzanese de Cardiologia. BR
  • Bertolami, Marcelo C; Instituto Dante Pazzanese de Cardiologia. BR
  • Ferreira, Waldinai P; Instituto Dante Pazzanese de Cardiologia. BR
  • Abdalla, Dulcineia SP; Instituto Dante Pazzanese de Cardiologia. BR
  • Faludi, Andre A; Instituto Dante Pazzanese de Cardiologia. BR
  • Nakamura, Yara; Instituto Dante Pazzanese de Cardiologia. BR
  • Bricharello, Liliana P; Instituto Dante Pazzanese de Cardiologia. BR
J Cardiovasc Pharmacol ; 55: 1-5, 2010.
Article en En | SES-SP, SESSP-IDPCPROD, SES-SP | ID: biblio-1063650
Biblioteca responsable: BR79.1
Ubicación: BR79.1
ABSTRACT

Background:

Coadministration of any statin with ezetimibe is as effective as using high doses of the same statin in the reduction of low-density lipoprotein cholesterol (LDL-c). There may be other effects called pleiotropics.

Objective:

To compare the effectiveness of 2 different treatments that obtain equivalent LDL-c reductions (80 mg of simvastatin, once a day and coadministration of 10 mg of simvastatin and 10 mg of ezetimibe, once a day) over endothelial function and inflammation.

Methods:

Twenty-three randomized patients with hypercholesterolemia in a 2 3 2 crossover protocol were studied. Endothelial function was analyzed by ultrasound assessment of endothelial dependent flow-mediated vasodilation of the brachial artery, and inflammation was estimated by high-sensitivity C-reactive protein (hs-CRP).

Results:

LDL-c reduction was similar between the 2 treatments with simvastatin/ezetimibe and with simvastatin (P , 0.001); no difference between treatments was found (P = 0.968). Both treatments improved significantly the endothelial function [3.61% with simvastatin/
Asunto(s)
Buscar en Google
Añadir a Mi BVS
Imprimir
XML
Colección: 06-national / BR Base de datos: SES-SP / SESSP-IDPCPROD Asunto principal: Endotelio / Hipercolesterolemia Tipo de estudio: Clinical_trials / Guideline Idioma: En Revista: J Cardiovasc Pharmacol Año: 2010 Tipo del documento: Article
Buscar en Google
Añadir a Mi BVS
Imprimir
XML
Colección: 06-national / BR Base de datos: SES-SP / SESSP-IDPCPROD Asunto principal: Endotelio / Hipercolesterolemia Tipo de estudio: Clinical_trials / Guideline Idioma: En Revista: J Cardiovasc Pharmacol Año: 2010 Tipo del documento: Article