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PTCH1 gene mutations in exon 17 and loss of heterozygosity on D9S180 microsatellite in sporadic and inherited human basal cell carcinomas
Santos, Daniela C. C; Zaphiropoulos, Peter G; Neto, Cyro F; Pimentel, Eugenio R. A; Sanches Jr, José A; Ruiz, Itamar R. G.
Afiliación
  • Santos, Daniela C. C; Instituto Butantan. São Paulo. BR
  • Zaphiropoulos, Peter G; s.af
  • Neto, Cyro F; s.af
  • Pimentel, Eugenio R. A; s.af
  • Sanches Jr, José A; s.af
  • Ruiz, Itamar R. G; Instituto Butantan. São Paulo. BR
International Jounal of Dermatology ; 50(7): 838-843, Jun 23, 2011.
Article en En | SES-SP, SESSP-IBPROD, SES-SP, SESSP-IBACERVO | ID: biblio-1063599
Biblioteca responsable: BR78.1
Ubicación: BR78.1
ABSTRACT
Basal cell carcinomas (BCCs) are the most frequent human cancer thatresults from malignant transformation of basal cells in the epidermis. Gorlin syndrome is a rare inherited autosomal dominant disease that predisposes with multiple BCCs and other birth defects. Both sporadic and inherited BCCs are associated with mutations in the tumor suppressor gene PTCH1, but there is still uncertainty on the role of its homolog PTCH2.
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Colección: 06-national / BR Base de datos: SES-SP / SESSP-IBACERVO / SESSP-IBPROD Asunto principal: Carcinoma Basocelular / Síndrome del Nevo Basocelular / Exones Límite: Humans Idioma: En Revista: International Jounal of Dermatology Año: 2011 Tipo del documento: Article
Buscar en Google
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Colección: 06-national / BR Base de datos: SES-SP / SESSP-IBACERVO / SESSP-IBPROD Asunto principal: Carcinoma Basocelular / Síndrome del Nevo Basocelular / Exones Límite: Humans Idioma: En Revista: International Jounal of Dermatology Año: 2011 Tipo del documento: Article