The genetic diversity of Plasmodium malariae and Plasmodium brasilianum from human, simian and mosquito hosts in Brazil
Acta Tropica
; 124(1): 27-32, Jun, 2012. map, tab, graf
Article
en En
| SES-SP, SESSP-SUCENPROD, SES-SP
| ID: biblio-1059322
Biblioteca responsable:
BR93.2
Ubicación: BR93.2
ABSTRACT
Plasmodium malariae is a protozoan parasite that causes malaria in humans and is genetically indistinguish able from Plasmodium brasilianum, a parasite infecting New World monkeys in Central and South America. P. malariae has a wide and patchy global distribution in tropical and subtropical regions, being found in South America, Asia, and Africa. However, little is known regarding the genetics of these parasites and the similarity between them could be because until now there are only a very few genomic sequences available from simian Plasmodium species. This study presents the first molecular epidemiological data for P. malariae and P. brasilianum from Brazil obtained from different hosts and uses them to explore the genetic diversity in relation to geographical origin and hosts. By using microsatellite genotyping, we discovered that of the 14 human samples obtained from areas of the Atlantic forest, 5 different multilocus genotypes were recorded, while in a sample from an infected mosquito from the same region a different haplo type was found. We also analyzed the longitudinal change of circulating plasmodial genetic profile in two untreated non-symptomatic patients during a 12-months interval...
Palabras clave
Texto completo:
1
Colección:
06-national
/
BR
Base de datos:
SES-SP
/
SESSP-SUCENPROD
Asunto principal:
Plasmodium malariae
/
Malaria
Límite:
Animals
/
Humans
País/Región como asunto:
America do sul
/
Brasil
Idioma:
En
Revista:
Acta Tropica
Año:
2012
Tipo del documento:
Article