Human platelet antigen-3 polymorphism as a risk factor for rheumatological manifestations in hepatitis C
Rev. Soc. Bras. Med. Trop
; 53: e20190210, 2020. tab
Article
en En
| LILACS
| ID: biblio-1057300
Biblioteca responsable:
BR1.1
ABSTRACT
Abstract INTRODUCTION:
Hepatitis C virus (HCV) infection is involved in the pathogenesis of autoimmune and rheumatic disorders. Although the human platelet antigens (HPA) polymorphism are associated with HCV persistence, they have not been investigated in rheumatological manifestations (RM). This study focused on verifying associations between allele and genotype HPA and RM in patients with chronic hepatitis C.METHODS:
Patients (159) with chronic hepatitis C of both genders were analyzed.RESULTS:
Women showed association between HPA-3 polymorphisms and RM.CONCLUSIONS:
An unprecedented strong association between rheumatological manifestations and HPA-3 polymorphism, possibly predisposing women to complications during the disease course, was observed.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
LILACS
Asunto principal:
Polimorfismo Genético
/
Enfermedades Reumáticas
/
Antígenos de Plaqueta Humana
/
Hepatitis C Crónica
Tipo de estudio:
Etiology_studies
/
Risk_factors_studies
Límite:
Adolescent
/
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Rev. Soc. Bras. Med. Trop
Asunto de la revista:
MEDICINA TROPICAL
Año:
2020
Tipo del documento:
Article
País de afiliación:
Brasil
Pais de publicación:
Brasil