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In Silico Target Identification and Validation for Antioxidant and Anti-inflammatory Activity of Selective Phytochemicals
Rana, Shikha; Dixit, Savita; Mittal, Alok.
Afiliación
  • Rana, Shikha; Maulana Azad National Institute of Technology. Chemistry Department. Bhopal. IN
  • Dixit, Savita; Maulana Azad National Institute of Technology. Chemistry Department. Bhopal. IN
  • Mittal, Alok; Maulana Azad National Institute of Technology. Chemistry Department. Bhopal. IN
Braz. arch. biol. technol ; 62: e19190048, 2019. tab, graf
Article en En | LILACS | ID: biblio-1055378
Biblioteca responsable: BR1.1
ABSTRACT
Abstract Phytochemicals present in plant extract include a number of biological active compounds which have shown promising antioxidant and anti-inflammatory activities in many animal studies. Present knowledge about the biochemical interactions of these compounds present in phytochemical extracts and target enzymes or proteins responsible for antioxidant and anti-inflammatory activity is limited. Present work is an attempt to identify and validate possible biological targets as enzymes or proteins involved in these targeted studies using molecular docking as computational method. IMPPAT Indian Medicinal Plants, Photochemistry and Therapeutics (a curated database) has been used to retrieve various phytochemicals derived from selected plants which includes Carica papaya, Citrus limon, Curcuma longa, Dalbergia sissoo and Punica granatum. These phytochemicals are further evaluated using molecular docking against three enzymes involved in antioxidant activity which includes Superoxide dismutase (SOD), Glutathione peroxidase (GPX) and Catalase (CAT). Cyclooxigenase-2 (COX-2) has been tested for anti-inflammatory activity of these phytochemicals. Gliadin (Triticum aestivum), Tea Extract (Punica granatum), Hesperidin (Citrus limon), Terrestribisamide (Triticum aestivum), Vitamin P (Carica papaya) and 1,2,6-Trigalloylglucose (Punica granatum) are few phytochemicals which has shown promising binding affinities towards target proteins or enzymes Superoxide dismutase (SOD), Glutathione peroxidase (GPX) and Catalase (CAT) and cyclooxigenase-2 (COX-2).
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Texto completo: 1 Colección: 01-internacional Base de datos: LILACS Asunto principal: Fitoquímicos / Antiinflamatorios / Antioxidantes Tipo de estudio: Diagnostic_studies Idioma: En Revista: Braz. arch. biol. technol Asunto de la revista: BIOLOGIA Año: 2019 Tipo del documento: Article País de afiliación: India Pais de publicación: Brasil
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: LILACS Asunto principal: Fitoquímicos / Antiinflamatorios / Antioxidantes Tipo de estudio: Diagnostic_studies Idioma: En Revista: Braz. arch. biol. technol Asunto de la revista: BIOLOGIA Año: 2019 Tipo del documento: Article País de afiliación: India Pais de publicación: Brasil