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Effects of tadalafil to prevent injury on corpus cavernosum after vascular or nervous peri-prostatic bundle injury. Experimental model in rats
Toledo, Antônio Carlos de; Kawano, Paulo Roberto; Yamamoto, Hamilto Akihissa; Guerra, Rodrigo; Gomes Filho, Fernando Ferreira; Pajolli, Pedro Ivo Rochetti; Amaro, João Luiz; Cardoso, Luiz Eduardo Macedo; Sampaio, Francisco José.
Afiliación
  • Toledo, Antônio Carlos de; s.af
  • Kawano, Paulo Roberto; UNESP. Botucatu School of Medicine. Department of Urology. Botucatu. BR
  • Yamamoto, Hamilto Akihissa; UNESP. Botucatu School of Medicine. Department of Urology. Botucatu. BR
  • Guerra, Rodrigo; UNESP. Botucatu School of Medicine. Department of Urology. Botucatu. BR
  • Gomes Filho, Fernando Ferreira; UNESP. Botucatu School of Medicine. Postgraduate Program in Bases General Surgery. Botucatu. BR
  • Pajolli, Pedro Ivo Rochetti; UNESP. Botucatu School of Medicine. Department of Urology. Botucatu. BR
  • Amaro, João Luiz; UNESP. Botucatu School of Medicine. Department of Urology. Botucatu. BR
  • Cardoso, Luiz Eduardo Macedo; Universidade Estadual do Rio de Janeiro. Urogenital Research Unit. BR
  • Sampaio, Francisco José; UERJ. Urogenital Research Unit. Rio de Janeiro. BR
Acta cir. bras ; Acta cir. bras;34(9): e201900901, 2019. tab
Article en En | LILACS | ID: biblio-1054695
Biblioteca responsable: BR1.1
ABSTRACT
Abstract

Purpose:

To evaluate the effects of tadalafil (TD) in preventing histological alterations of the corpus cavernosum caused by isolated lesions of cavernous nerve (ILCN) and artery (ILCA) in rats.

Methods:

Fifty male Wistar rats were randomly assigned in five groups G1 control; G2 bilateral ILCN; G3 bilateral ILCA; G4 ILCN+TD; G5 ILCA+TD. The cavernous bodies were submitted to histomorphometry, immunohistochemistry and biochemical analysis.

Results:

Nerve density was significantly higher in G2 and G4 compared to control (22.62±2.84 and 19.53±3.47 vs. 15.72±1.82; respectively, p<0.05). Smooth muscle density was significantly lower in G2 and G3 in comparison to G1 (12.87±1.90 and 18.93±1.51 vs. 21.78±1.81, respectively; p<0.05). A significant decrease in the sinusoidal lumen area was observed in G2 compared to controls (5.01±1.62 vs. 9.88±3.66, respectively; p<0.05) and the blood vessel density was increased in G2 and G3 (29.32±4.13 e 20.80±2.47 vs. 10.13±2.71, p<0.05). Collagen density was higher in G3 compared to G1 (93.76±15.81 vs. 64.59±19.25; p<0.05).

Conclusions:

Histomorphometric alterations caused by ILCN were more intense than those produced by vascular injury, but the collagen analyses showed more fibrosis in animals with ILCA. TD was effective in preventing the majority of the alterations induced by the periprostatic bundle injury.
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Texto completo: 1 Colección: 01-internacional Base de datos: LILACS Asunto principal: Pene / Sustancias Protectoras / Inhibidores de Fosfodiesterasa 5 / Traumatismos de los Nervios Periféricos / Tadalafilo Tipo de estudio: Evaluation_studies Límite: Animals Idioma: En Revista: Acta cir. bras Asunto de la revista: Cirurgia Geral / Procedimentos Cir£rgicos Operat¢rios Año: 2019 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Brasil
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: LILACS Asunto principal: Pene / Sustancias Protectoras / Inhibidores de Fosfodiesterasa 5 / Traumatismos de los Nervios Periféricos / Tadalafilo Tipo de estudio: Evaluation_studies Límite: Animals Idioma: En Revista: Acta cir. bras Asunto de la revista: Cirurgia Geral / Procedimentos Cir£rgicos Operat¢rios Año: 2019 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Brasil