Your browser doesn't support javascript.
loading
Human Cytomegalovirus DNA Quantification and Gene Expression in Gliomas of Different Grades
Stangherlin, Lucas M; Castro, Fabiane Lucy F; Medeiros, Raphael Salles S; Guerra, Juliana Mariotti; Kimura, Lidia Midori; Shirata, Neuza K; Nonogaki, Suely; Dos Santos, Claudia Januário; Carlan Silva, Maria Cristina.
Afiliación
  • Stangherlin, Lucas M; Universidade Federal do ABC. BR
  • Castro, Fabiane Lucy F; Universidade Federal do ABC. BR
  • Medeiros, Raphael Salles S; Universidade de São Paulo. BR
  • Guerra, Juliana Mariotti; Secretaria da Saúde do Estado de São Paulo. Instituto Adolfo Lutz. BR
  • Kimura, Lidia Midori; Secretaria da Saúde do Estado de São Paulo. Instituto Adolfo Lutz. BR
  • Shirata, Neuza K; Secretaria da Saúde do Estado de São Paulo. Instituto Adolfo Lutz. BR
  • Nonogaki, Suely; Secretaria da Saúde do Estado de São Paulo. Instituto Adolfo Lutz. BR
  • Dos Santos, Claudia Januário; Universidade Federal do ABC. BR
  • Carlan Silva, Maria Cristina; Universidade Federal do ABC. BR
Plos one ; 11(7)2016.
Article en En | LILACS, SES-SP | ID: biblio-1024785
Biblioteca responsable: BR91.2
ABSTRACT
Gliomas are the most common type of primary brain tumors. The most aggressive type, Glioblastoma multiforme (GBM), is one of the deadliest human diseases, with an average survival at diagnosis of about 1 year. Previous evidence suggests a link between human cytomegalovirus (HCMV) and gliomas. HCMV has been shown to be present in these tumors and several viral proteins can have oncogenic properties in glioma cells. Here we have investigated the presence of HCMV DNA, RNA and proteins in fifty-two gliomas of different grades of malignancy. The UL83 viral region, the early beta 2.7 RNA and viral protein were detected in 73%, 36% and 57% by qPCR, ISH and IHC, respectively. Positivity of the viral targets and viral load was independent of tumor type or grade suggesting no correlation between viral presence and tumor progression. Our results demonstrate high prevalence of the virus in gliomas from Brazilian patients, contributing to a better understanding of the association between HCMV infection and gliomas worldwide and supporting further investigations of the virus oncomodulatory properties.
Asunto(s)
Texto completo
Añadir a Mi BVS
Imprimir
XML
Buscar en Google
Texto completo: 1 Colección: 01-internacional Base de datos: LILACS / SES-SP Asunto principal: Proteínas Virales / Brasil / Humanos / ARN Viral / Inmunohistoquímica / Hibridación in Situ / Infecciones por Citomegalovirus / Carga Viral / Citomegalovirus / Glioma Tipo de estudio: Risk_factors_studies País/Región como asunto: America do sul / Brasil Idioma: En Revista: Plos one Asunto de la revista: CIENCIA / MEDICINA Año: 2016 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
Buscar en Google
Texto completo: 1 Colección: 01-internacional Base de datos: LILACS / SES-SP Asunto principal: Proteínas Virales / Brasil / Humanos / ARN Viral / Inmunohistoquímica / Hibridación in Situ / Infecciones por Citomegalovirus / Carga Viral / Citomegalovirus / Glioma Tipo de estudio: Risk_factors_studies País/Región como asunto: America do sul / Brasil Idioma: En Revista: Plos one Asunto de la revista: CIENCIA / MEDICINA Año: 2016 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Estados Unidos