Effect of taxifolin on oxidative gastric injury induced by celiac artery ligation in rats
Acta cir. bras
; 34(4): e201900404, 2019. tab, graf
Article
en En
| LILACS
| ID: biblio-1001088
Biblioteca responsable:
BR1.1
ABSTRACT
Abstract Purpose:
To examine the effect of taxifolin on I/R induced gastric injury in rats using biochemical and histopatholohical methods.Methods:
Eighteen albino Wistar male rats equally grouped as; gastric I/R (I/R), 50 mg/kg taxifolin + gastric I/R (TAX+ I/R) and sham operation applied (SHAM). Ischemia induced for 1 hour, and reperfusion induced for 3 hours.Results:
Oxidant parameters like, Malondialdehyde (MDA) and Hydroxyguanine (8-OHdG) were higher, whereas total glutathione (tGSH) was lower in the I/R group according to SHAM group, histopathological findings such as marked destruction, edema, and proliferated dilated congested blood vessels were observed severely in the I/R group, whereas there was not any pathological finding except mild dilated congested blood vessels in the TAX+ I/R group.Conclusion:
The taxifolin can be clinically beneficial in the treatment of gastric injury due to I/R procedure.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
LILACS
Asunto principal:
Quercetina
/
Daño por Reperfusión
/
Antiinflamatorios no Esteroideos
/
Mucosa Gástrica
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
Acta cir. bras
Asunto de la revista:
CIRURGIA GERAL
/
Procedimentos Cir£rgicos Operat¢rios
Año:
2019
Tipo del documento:
Article
País de afiliación:
Turquía
Pais de publicación:
Brasil