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Rev Cubana Med Trop ; 59(3): 227-33, 2007.
Artigo em Espanhol | MEDLINE | ID: mdl-23427461

RESUMO

The study of 422 non-01 Vibrio cholerae strains from nine provinces, 9 of them isolated from a water-borne disease outbreak, was performed. All the strains exhibited antimicrobial susceptibility and virulence factors. The nine strains from the outbreak were subjected to a DNA macrorestriction study based on the pulsed field electrophoresis technique. For the first time in Cuba and the Caribbean. The circulation of atypical non-01 V cholerae strains (resistent to vibriostatic compound 0129 and trimethoprim/sulfamethoxazole). The behavior of antimicrobial susceptibility evinced for the first time the circulation of two different resistence patterns in Cuba (ampicilline, trimethoprim/ sulfamethoxazole, sulfonamide and tetracycline, trimethoprim/ sulfamethoxazole, sulfonamide). The frequency of trimethoprim/ sulfamethoxazole-resistent strains was similar during the whole period of study. However, resistance to ampicilline decreased whereas resistance to tetracycline increased. The main found virulence factors were gelatinase, hemolysine, elastase and adherence to Hep-2 cells. On the other hand, the outbreak strains showed higher percentages than the others due to the presence of heat-liable toxin and fimbriae. The results of the molecular and epidemiological studies allowed giving a speedy and accurate response that explained the etiology of the first food-borne disease outbreak.


Assuntos
Vibrio cholerae não O1/isolamento & purificação , Antígenos de Bactérias/análise , Aderência Bacteriana , Proteínas de Bactérias/análise , Linhagem Celular , Cólera/epidemiologia , Cólera/microbiologia , Toxina da Cólera/análise , Cuba/epidemiologia , DNA Bacteriano/análise , Surtos de Doenças , Resistência Microbiana a Medicamentos , Eletroforese em Gel de Campo Pulsado , Fezes/microbiologia , Fímbrias Bacterianas/ultraestrutura , Humanos , Vibrio cholerae não O1/efeitos dos fármacos , Vibrio cholerae não O1/fisiologia , Vibrio cholerae não O1/ultraestrutura , Virulência , Microbiologia da Água
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