RESUMO
La Varicela es una enfermedad viral que se presenta con frecuencia en la población infantil, cursa con lesiones cutáneas y en ciertas ocasiones en cavidad bucal. Se presenta un caso de paciente masculino de 5 años de edad, quien consulta por presentar lesiones en cavidad bucal, ademàs de las lesiones cutáneas. Fue tratado con antivirales tópico y sistémico, notándose mejoría de las lesiones en dos semanas.
The Chicken pox is a viral infection that is presented frequently in the infantile population, it presented with skin lesions and, in certain occasions, in oral cavity. A 5 years old male patient, who consult for present vesicles in oral cavity and skin lesions, it was treated with topical and systemic antiviral, being noticed improvement of the lesions in two weeks.
Assuntos
Humanos , Masculino , Pré-Escolar , Doenças da Boca/classificação , /patogenicidade , Varicela/diagnóstico , Varicela/tratamento farmacológico , Antivirais/uso terapêutico , Vacina contra Varicela , Doenças da Boca/patologia , Varicela/microbiologiaRESUMO
The purpose of the present study was to determine whether a high number of bacteria could be demonstrated in the upper small bowel during the chickenpox infection. Intestinal juice was drawn in nine malnourished children, during and two weeks after the acute period of the disease. The results of the study fail to demonstrate quantitative differences in the bacterial flora of the small bowel in both periods. Besides that, the bacterial overgrowth previously reported in malnutrition, is confirmed.
Assuntos
Bactérias/isolamento & purificação , Varicela/microbiologia , Transtornos da Nutrição Infantil/microbiologia , Intestino Delgado/microbiologia , Bactérias Aeróbias/isolamento & purificação , Bactérias Anaeróbias/isolamento & purificação , Varicela/complicações , Transtornos da Nutrição Infantil/complicações , Transtornos da Nutrição Infantil/imunologia , Transtornos da Nutrição Infantil/fisiopatologia , Pré-Escolar , Feminino , Ácido Gástrico/metabolismo , Conteúdo Gastrointestinal/microbiologia , Humanos , Síndromes de Imunodeficiência/complicações , Lactente , MasculinoRESUMO
STUDY OBJECTIVE: To determine whether acyclovir administered orally affects the duration and severity of varicella in otherwise normal children. DESIGN: Randomized, placebo-controlled, double-blind trial. SETTING: Patients' residence and university hospital clinic. PATIENTS: One hundred five children between 5 and 16 years of age with laboratory-confirmed varicella entered the study. Of the 102 who were included in the final analysis, 50 received acyclovir and 52 received placebo. INTERVENTION: Placebo or acyclovir was given orally four times daily, for 5 to 7 days. The acyclovir dose was adjusted as follows: 5 to 7 years of age, 20 mg/kg; 7 to 12 years, 15 mg/kg; and 12 to 16 years, 10 mg/kg. MEASUREMENTS AND MAIN RESULTS: Acyclovir recipients, compared with the placebo group, defervesced sooner (median, 1 day vs 2 days; p = 0.001), experienced onset of cutaneous healing sooner, as reflected by a decrease in number of lesions (median, 3 days vs 2 days; p = 0.002), and had fewer skin lesions (median, 500 vs 336; p = 0.02). Acyclovir did not significantly change the rate of complications of varicella (10% in the acyclovir group vs 13.5% among placebo subjects). Adverse drug effects were not observed. Acyclovir recipients had lower geometric mean serum antibody titers to varicella-zoster virus than their placebo counterparts 4 weeks after the onset of illness, but antibody titers in both groups were similar 1 year later. CONCLUSIONS: These results provide evidence that acyclovir is useful and well tolerated for treatment of varicella in otherwise healthy children.