RESUMO

A new member of the phlebovirus genus, tentatively named Granada virus, was detected in sandflies collected in Spain. By showing the presence of specific neutralizing antibodies in human serum collected in Granada, we show that Granada virus infects humans. The analysis of the complete genome of Granada virus revealed that this agent is likely to be a natural reassortant of the recently described Massilia virus (donor of the long and short segments) with a yet unidentified phlebovirus (donor of the medium segment).

Assuntos

Febre por Flebótomos/virologia , Psychodidae/virologia , Vírus da Febre do Flebótomo Napolitano/classificação , Vírus da Febre do Flebótomo Napolitano/genética , Animais , Anticorpos Antivirais/sangue , Sequência de Bases , Chlorocebus aethiops , Feminino , Genoma Viral , Humanos , Insetos Vetores/virologia , Masculino , Dados de Sequência Molecular , Febre por Flebótomos/epidemiologia , Filogenia , Vírus Reordenados , Vírus da Febre do Flebótomo Napolitano/imunologia , Estudos Soroepidemiológicos , Células Vero