RESUMO
Background: In dogs, abdominal testes have higher risk of malignant transformation, and the Sertoli cell tumor is the most common type of testicular cancer in the species. This neoplasia can lead to an increase on estrogen production, causing a paraneoplastic feminization syndrome with dermatologic, behavioral and blood repercussions. When located inside the abdomen, the Sertoli cell tumor can compress adjacent organs, worsening the prognosis. Thus, this study aimed to report a case of an intra-abdominal Sertoli cell tumor in a dog associated to multiple organic complications.Case: A 4-year-old male Shih-tzu was admitted at the Veterinary Hospital of Universidade Federal Rural do Semi-Árido (UFERSA), with a history of abdominal cryptorchidism and the development of dermatological signs, such as alopecia and hyperpigmentation, with an evolution of two months. At physical examination it was observed alopecia on lumbosacral region and on hind limbs, hyperpigmentation, gynecomastia and pendulous prepuce, suggestive of feminization syndrome. A firm mass was palpated on caudal abdomen. The following exams were requested: complete blood cell count, serum biochemistry (alanine aminotransferase, alkaline phosphatase, creatinine and urea), abdominal ultrasonography and fine needle aspiration cytology of the abdominal mass. Hematological and biochemistry profile were within the normal range for the species. On the ultrasonography, regular and rounded structures were observed, suggesting ectopic testes (left testis: 2.37 x 2.95 cm; right testis: 1.92 x 1.38 cm). The left testis presented characteristics of malignant transformation. The cytology of the abdominal mass suggested Sertoli cell tumor. The dog was submitted to an exploratory laparotomy. The right testis was atrophied and its orchiectomy was performed.[...]
Assuntos
Masculino , Animais , Cães , Neoplasias Testiculares/veterinária , Tumor de Células de Sertoli/complicações , Tumor de Células de Sertoli/diagnóstico por imagem , Tumor de Células de Sertoli/veterinária , Criptorquidismo/complicações , Criptorquidismo/veterináriaRESUMO
Background: In dogs, abdominal testes have higher risk of malignant transformation, and the Sertoli cell tumor is the most common type of testicular cancer in the species. This neoplasia can lead to an increase on estrogen production, causing a paraneoplastic feminization syndrome with dermatologic, behavioral and blood repercussions. When located inside the abdomen, the Sertoli cell tumor can compress adjacent organs, worsening the prognosis. Thus, this study aimed to report a case of an intra-abdominal Sertoli cell tumor in a dog associated to multiple organic complications.Case: A 4-year-old male Shih-tzu was admitted at the Veterinary Hospital of Universidade Federal Rural do Semi-Árido (UFERSA), with a history of abdominal cryptorchidism and the development of dermatological signs, such as alopecia and hyperpigmentation, with an evolution of two months. At physical examination it was observed alopecia on lumbosacral region and on hind limbs, hyperpigmentation, gynecomastia and pendulous prepuce, suggestive of feminization syndrome. A firm mass was palpated on caudal abdomen. The following exams were requested: complete blood cell count, serum biochemistry (alanine aminotransferase, alkaline phosphatase, creatinine and urea), abdominal ultrasonography and fine needle aspiration cytology of the abdominal mass. Hematological and biochemistry profile were within the normal range for the species. On the ultrasonography, regular and rounded structures were observed, suggesting ectopic testes (left testis: 2.37 x 2.95 cm; right testis: 1.92 x 1.38 cm). The left testis presented characteristics of malignant transformation. The cytology of the abdominal mass suggested Sertoli cell tumor. The dog was submitted to an exploratory laparotomy. The right testis was atrophied and its orchiectomy was performed.[...](AU)
Assuntos
Animais , Masculino , Cães , Tumor de Células de Sertoli/complicações , Tumor de Células de Sertoli/diagnóstico por imagem , Tumor de Células de Sertoli/veterinária , Neoplasias Testiculares/veterinária , Criptorquidismo/complicações , Criptorquidismo/veterináriaRESUMO
Tumores da genitália de machos só não são mais incidentes que ostumores cutâneos. Os tumores testiculares são raros na maioria das espéciesdomésticas, ocorrendo com maior frequência nos cães. O Sertolioma está entre astrês mais frequentes neoplasias testiculares de cães, ao lado de tumores dascélulas de Leydig e seminomas. Vários fatores podem influenciar odesenvolvimento de tumores testiculares no cão, incluindo criptorquidismo, idade,raça e exposição a fatores cancerígenos. Há uma associação significativa entrecriptorquidismo e o desenvolvimento de tumores de células de Sertoli eseminomas. A maioria dos cães com tumores testiculares são assintomáticos, e aneoplasia testicular é geralmente um achado acidental. Os tumores das células deSertoli são comumente localmente invasivos e raramente metastáticos, mas sabeseque os tumores intra-abdominais possuem maior índice metastático. Estetrabalho visa relatar um caso de tumor das células de Sertoli com metástase emrim esquerdo em um cão SRD de 7 anos, criptorquida bilateral, submetido aorquiectomia e nefrectomia esquerda, e posterior tratamento quimioterápico comdoses alternadas de carboplatina e doxorrubicina , e até o presente momento seapresentando em completa remissão.
Tumors of male genitalia are not only more incidents than skin tumors.Testicular tumors are rare in most domestic species, occurring more frequently indogs. The Sertolioma is among the three most frequent testicular neoplasms indogs, besides Leydig cell tumors and seminomas. Several factors may influencethe development of testicular tumors in dogs, including cryptorchidism, age, raceand exposure to carcinogenic factors. There is a significant association betweencryptorchidism and tumor development of Sertoli cells and seminomas. Most dogswith testicular tumors are asymptomatic, and testicular cancer is usually anincidental finding. The Sertoli cell tumors are usually locally invasive and rarelymetastatic, but it is known that the intra-abdominal tumors have a higher metastaticrate. This paper describes a case of Sertoli cell tumor with metastasis in the leftkidney in a seven years old, male, mongrel dog, bilateral cryptorchid , submitted toorchiectomy and left nephrectomy and subsequent chemotherapy with alternatingdoses of doxorubicin and carboplatin every 21 days, and until now performing incomplete remission.
Assuntos
Masculino , Animais , Cães , Metástase Neoplásica , Neoplasias Testiculares , Rim , Testículo/patologia , Tratamento Farmacológico , Tumor de Células de Sertoli/complicaçõesRESUMO
Las neoplasias del testículo no son muy frecuentes en los animales domésticos Los caninos son los que las manifiestan con mayor frecuencia; estando entre los 0.7 y 4.6% de todos los tumores que sufren. Algunos factores se han asociado como predisponentes: entre ellos la edad madura y la presencia del criptorquidia uni o principalmente bilateral. Las neoplasias del testículo más frecuente son el tumor de células de Sertoli, el tumor de células de Leydig y los seminomas, que en general presentan la conducta benigna. El tratamiento recomendado previa evaluación clínica, es la orquiectomía (uni o bilateral), incluidos en los casos de criptorquidismo el testículo alojado en el escroto. En el presente manuscrito se realiza una revisión del tema en su primera parte; en la segunda, se describe el caso de un tumor de células del Sertoli en un canino Cocker que presentó al examen clínico un testículo retenido y síndrome feminizante. En este se caso se efectuó el diagnóstico histopatológico después de la extracción quirúrgica de la masa abdominal y también se realizó la extirpación del testículo alojado en el escroto.
Assuntos
Animais , Cães , Dente Canino , Tumor de Células de Sertoli , Dente Canino/anormalidades , Dente Canino/cirurgia , Dente Canino/fisiopatologia , Tumor de Células de Sertoli/complicações , Tumor de Células de Sertoli/congênito , Tumor de Células de Sertoli/terapia , Tumor de Células de Sertoli/veterináriaRESUMO
OBJECTIVES: To report one case of Sertoli cell testicular tumor of the large cell calcifying type, a rare presentation, and to perform a medical literature review on the topic. METHODS: Our case report is based on the patient's medical history and images of the diagnostic tests and pathology. We perform a bibliographic review of the available literature in MEDLINE. RESULTS: The case is reported with the diagnostic tests and pathology report. We present a comprehensive review of the medical literature on the topic. CONCLUSIONS: The large cell calcifying Sertoli cell tumor is a rare testicular tumor of benign behaviour. Due to its benign behaviour, treatment of this kind of tumor should be conservative with resection of the lesion, preserving the testicle.