RESUMO
Tissue degeneration, infection, inflammation, cancer, trauma, surgery and limb fractures all produce pain. Each of these physiological abnormalities requires a therapeutic approach different from the last. In acute pain, caused by fracture, several classes of analgesics have been utilized. These basic remedies for analgesia, however, are still confined to a small number of medications, including nonsteroidal anti-inflammatory drugs (NSAIDs), local anesthetics and opioids. In addition, most of these drugs have side effects, limiting their use in clinical practice. The purpose of this study was to compare the efficacy of three NSAIDs to relief acute pain caused by ankle fracture. Sixty subjects with ankle fracture were randomized to receive ketorolac, diclofenac, or etoricoxib, every 12 hours in a prospective, double-blind study. Forty-nine patients completed the study. The subjects' assessments of ankle pain on the visual analog scale and a Likert scale showed a significant reduction from baseline over 24 hr, regardless the treatment group. All treatments showed a similar profile in pain reduction. Etoricoxib, diclofenac and ketorolac twice daily are a rapid and effective treatment for acute pain. All the regimens were well tolerated in this study.
Assuntos
Dor Aguda/tratamento farmacológico , Traumatismos do Tornozelo/tratamento farmacológico , Anti-Inflamatórios não Esteroides/uso terapêutico , Diclofenaco/uso terapêutico , Fraturas Ósseas/tratamento farmacológico , Cetorolaco/uso terapêutico , Piridinas/uso terapêutico , Sulfonas/uso terapêutico , Adulto , Traumatismos do Tornozelo/fisiopatologia , Método Duplo-Cego , Etoricoxib , Fraturas Ósseas/fisiopatologia , Humanos , Pessoa de Meia-Idade , Estudos ProspectivosRESUMO
We sought to determine whether valdecoxib is as effective as diclofenac in treating acute ankle sprain. Patients (n=202) with acute first- and second-degree ankle sprain were randomized to valdecoxib (40 mg twice daily on day 1 followed by 40 mg once daily on days 2-7) or diclofenac (75 mg twice daily). The primary efficacy end-point was the Patient's Assessment of Ankle Pain visual analogue scale (VAS, 0-100 mm) value on day 4. Valdecoxib was as efficacious as diclofenac in treating the signs and symptoms of acute ankle sprain. The mean VAS reduction in ankle pain on day 4 was not different between groups; the two-sided 95% confidence interval for the between-group difference was within the prespecified limit for non-inferiority (10 mm). There were no significant differences between groups for all secondary efficacy end-points. The two treatments were similarly effective and well tolerated for treatment of acute ankle sprain.
Assuntos
Traumatismos do Tornozelo/tratamento farmacológico , Isoxazóis/administração & dosagem , Dor/tratamento farmacológico , Entorses e Distensões/tratamento farmacológico , Sulfonamidas/administração & dosagem , Adulto , Diclofenaco/administração & dosagem , Diclofenaco/farmacologia , Diclofenaco/toxicidade , Método Duplo-Cego , Dispepsia/induzido quimicamente , Feminino , Gastrite/induzido quimicamente , Humanos , Isoxazóis/farmacologia , Isoxazóis/toxicidade , Masculino , Pessoa de Meia-Idade , Medição da Dor , Entorses e Distensões/complicações , Sulfonamidas/farmacologia , Sulfonamidas/toxicidadeRESUMO
Foram avaliados 30 pacientes com patologias inflamatórias agudas nåo infecciosas do aparelho locomotor. Houve melhora total ou parcial de todas as principais manifestaçöes da inflamaçåo em todos os pacientes estudados. A tolerabilidade foi excelente, e a maioria dos pacientes obteve resposta clínica em até 1 hora após a ingeståo do nimesulide