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BACKGROUND: In Mexico, the Northern States are highly impacted by alcohol consumption and associated problems. Little is known about the association between contextual social disadvantage and alcohol use disorder in this region. METHODS: Information from 1265 current drinkers surveyed in the U.S.-Mexico Study on Alcohol and Related Conditions (UMSARC) was combined with official data on neighborhood disadvantage (index of urban marginalization, a composite of ten indicators of area-level social disadvantage) for 302 neighborhoods. Using statistical marginal models, we estimated the association of neighborhood disadvantage with alcohol use disorder (AUD; based on DSM-5 criteria), alone and with adjustment for individual and contextual covariates. We also tested for moderation of neighborhood disadvantage effects by sex, education, internal migration and border area. RESULTS: There was a statistically significant increase in the odds of AUD of 59% (AOR=1.59; 95%CI=1.03, 2.46) for every one-point increase on the neighborhood disadvantage scale, after adjustment for covariates. A significant interaction between sex and neighborhood disadvantage was indicated by two measures of additive interaction (AP=0.55; p<0.001 and S=2.55; p<0.001), with higher neighborhood disadvantage related to higher prevalence of AUD for men but not for women. No moderation effects were observed for education, internal migration or border area. CONCLUSIONS: Neighborhood disadvantage is a risk factor for AUD independent of other variables, specifically in men. Studies of contextual variables offer the possibility for understanding the role of collective circumstances on individuals in society. Future studies of alcohol use in this geographic area should consider effects of contextual determinants such as disadvantage.

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Little is known about the comorbidity of alcohol use, anxiety, hopelessness, and trauma among Mexican Americans, especially those living in impoverished and often isolated communities or neighborhoods (colonias in Spanish) along the U.S.-Mexico border that may be particularly vulnerable due to stressful living conditions. The current study utilized a community participatory model to investigate the relationships of alcohol use, acculturation, anxiety, hopelessness, and trauma in 100 Mexican origin colonia residents. Significant comorbidity was expected and that anxiety, hopelessness, and post-traumatic symptoms were hypothesized to be associated with the severity of the alcohol use disorders of participants. Participants who met DSM-IV criteria for alcohol dependence reported significantly more symptoms of anxiety and post-traumatic stress, and symptoms of anxiety were significantly associated with alcohol use disorders. This study provides evidence of the need for further investigation of stress, trauma, anxiety, hopelessness, and alcohol abuse in Mexican American residents and to inform future prevention and treatment efforts to improve both the physical and mental health of this population.

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Objetivo: El consumo de drogas afecta a los adolescentes de cualquier estrato social, con múltiples implicancias personales, familiares y sociales. El Instituto de Investigaciones Epidemiológicas de la Academia Nacional de Medicina y SEDRONAR se propusieron identificar un perfil del consumo en adolescentes escolarizados. Material y Métodos: en 2005 se encuestaron 1755 adolescentes de 15 a 18 años, escolarizados, del área denominado "Conurbano Bonaerense" correspondiente a la Provincia de Buenos Aires, mediante una encuesta anónima, voluntaria y autoadministrada, y un diseño probabilístico de escuelas públicas y privadas. Resultados: se detectó una prevalencia alta de consumo de alcohol, seguido de tabaco, marihuana, estimulantes y cocaína. Se encontraron factores asociados: consumo por algún familiar de los amigos, comunicación familiar, hacinamiento y actitudes de tolerancia hacia el consumo. Los resultados alcanzados señalan la necesidad de continuar los estudios sobre las motivaciones acerca del comportamiento de la transmisión de la adicción y los factores de vulnerabilidad y resiliencia.

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OBJECTIVE: To determine the prevalence of heavy alcohol consumption and factors associated with it in a Brazilian adult population. METHODS: Cross-sectional population-based study including 2,177 adults (aged 20 to 69), living in the urban area of the municipality of Pelotas, Rio Grande do Sul State, Brazil. The sample was selected in multiple stages. Heavy alcohol consumption was defined as above 30g/day. The adjusted analysis was conducted by logistic regression. RESULTS: The prevalence of heavy alcohol consumption was 14.3% (29.2% among men and 3.7% among women). The following groups presented higher prevalences of heavy alcohol consumption after adjusted analysis: men, elderly people, blacks or mulattoes, heavy smokers, and people who present some kind of chronic disease. Men with minor psychiatric disorders showed higher prevalences of heavy alcohol consumption than other men. Among women, association between age and heavy alcohol consumption was inversely related. Furthermore, the study indicates that among hypertensive subjects, those with heavy alcohol consumption presented worse disease management. CONCLUSIONS: Heavy alcohol consumption is high and results in countless negative consequences for the individual's health and quality of life. Our results highlight the high prevalence of heavy alcohol consumption and indicate subsections of the whole population more susceptible to alcoholism.

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Review paper about prospective studies concerning the natural history of alcoholism. Emphasizing Vaillant and the impact of his contribution to the evolution of the concepts of harmful use and dependence, as well as its most important therapeutic implications. The fact that the abstinence rates, in the treatment of a severe dependence, almost remaining the same in the last twenty-five years is highlighted.

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AIMS: To assess the prevalence of potential alcohol use disorders and associated factors using the Alcohol Use Disorders Identification Test (AUDIT). DESIGN: Cross-sectional study. SETTING: A town in southern Brazil. PARTICIPANTS: A representative sample of 1260 people aged 15 and over. MEASUREMENTS: Demographic, socioeconomic, smoking habit and mental health data were collected. Logistic regression was used in the multivariate analysis, and odds ratios (ORs) and 95% confidence intervals (CIs) were calculated. FINDINGS: Overall prevalence of alcohol use disorder was 7.9%, with 14.5% prevalence among men and 2.4% among women. The risk of alcohol misuse increased across social class (P linear trend = 0.03) and compared with the highest classes (A and B), groups C through E had ORs of 1.48, 1.51 and 2.36, respectively. Males had an OR of 6.89 (CI 3.61-13.16) compared with women. A linear trend was found (P = 0.001) between smoking categories, and smokers (OR 3.27; CI 1.91-5.58) and ex-smokers (OR 1.30; CI 0.56-2.98) were at higher risk than non-smokers. Those with minor psychiatric disorders had a 2.48 OR (CI 1.35-4.56) of presenting a positive test. CONCLUSIONS: The AUDIT detected a high prevalence of potential alcohol use disorders in the population sampled. Those identified are potential targets for preventive measures implemented through health policies.

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Indicadores bioquimicos e hematimetricos de inflamacao e lesao celular foram correlacionados com bilirrubina e enzimas hepaticas e pancreatica em 30 alcoolistas cronicos do sexo masculino internados em hospital psiquiatrico para desintoxicacao e tratamento do alcoolismo. A aspartato aminotransferase, alanino aminotransferase, gamaglumiltransferase, fosfatase alcalina e bilirrubina total estavam alteradas em 90(por cento), 63(por cento), 87(por cento), 23(por cento) e 23(por cento) dos casos, respectivamente. Entre os indicadores de inflamacao (desidrogenase latica, alterada em 16 dos casos; alfa-1 globulina, 24(por cento), alfa-2 globulina, 88(por cento); contagem de leucocitos, 28(por cento) nenhum estava correlacionado com as alteracoes da bilirrubina e enzimas hepaticas...

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The objective of the present experiment was to assess ethyl alcohol (ETOH) dependence brought about by a semivoluntary intermittent intake regimen in rats. Male Wistar rats weighing 150-250 g at the onset of the experiment were assigned to the following groups: 0% ETOH (N = 11), 5% ETOH (N = 20), 20% ETOH (N = 20) and 40% ETOH (N = 18). ETOH solutions were offered at the end of the day and overnight from Monday to Friday, and throughout weekends, for 90 days. The concentration of the ETOH solutions was increased in a stepwise fashion allowing the rats to get used to the taste of alcohol. Reposition of pure water was permitted during 1-h water drinking periods in the morning. Daily volume intake (+/- SEM) averaged 25.4 +/- 0.4 ml (0% ETOH), 23.8 +/- 0.6 ml (5% ETOH), 17.6 +/- 0.7 ml (20% ETOH) and 17.5 +/- 0.6 ml (40% ETOH). ETOH consumption differed significantly (P < 0.05) among groups, averaging 4.4 +/- 0.2 g kg-1 day-1 (5% ETOH), 10.3 +/- 0.3 g kg-1 day-1 (20% ETOH) and 26 +/- 1.2 kg-1 day-1 (40% ETOH). Furthermore, ETOH detection in plasma 10-12 h after offering the solution indicated that its consumption in the 40% ETOH group was sufficient to override its metabolism. Overt signs of ETOH dependence, such as increased thirst, hyperactivity, puffing, hair ruffling and startle responsiveness as well as reduced drowsiness, were significantly increased in the 20% and 40% ETOH groups compared to the 0% and 5% groups. Accordingly, the model described here proved to be a useful tool for the evaluation of subtle or moderate behavioral and physical consequences of long-term ETOH intake.

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