RESUMO
Since the discovery of isoniacid in 1952, it has become apparent that there are considerable variations in the manner in which individuals react to the drug. We studied 90 patients from La Paz (3.600 m. over sea level) and 50 patients from Santa Cruz (470 m. over sea level). Our results in the two groups tested suggest that the high altitude hypoxia increases the velocity of inactivation. Despite to the influence of hypoxia it was seen that both groups have the some frequency of rapid and slow inactivators.
Assuntos
Altitude , Arilamina N-Acetiltransferase/metabolismo , Hipóxia/enzimologia , Isoniazida/farmacocinética , Acetilação , Adolescente , Adulto , Idoso , Antituberculosos/farmacocinética , Antituberculosos/uso terapêutico , Arilamina N-Acetiltransferase/genética , Biotransformação/genética , Bolívia/epidemiologia , Criança , Quimioterapia Combinada/uso terapêutico , Feminino , Humanos , Isoniazida/uso terapêutico , Cinética , Fígado/enzimologia , Masculino , Pessoa de Meia-Idade , Fenótipo , Polimorfismo Genético , Estreptomicina/uso terapêutico , Tioacetazona/uso terapêutico , Tuberculose/tratamento farmacológico , Tuberculose/enzimologia , Tuberculose/epidemiologiaRESUMO
A comparative study with 2 tier and 3 tier combination of Rifampicin, Clofazimine, DDS, INAH and Thiacetazone was conducted on fifty lepromatous leprosy cases for varying periods. Assessment showed that 2 tier combination of clofazimine and DDS produced good results but the cost stood in the way; whereas 3 tier combination of DDS, thiacetazone and INAH also yielded good results with much less expenses to be incurred by the patients. Whether therapy with this 3 tier combination could be continued for a longer period with sustained improvement is yet to be assessed by further studies for a considerable period.