RESUMO

Three carbohydrate derivatives, MAG(3)-Gl, MAG(3)-Ga, MAG(3)-NG, were synthesized and radiolabeled in high yields. These substances were injected in health Swiss mice and their biodistribution were evaluated. Among them, (99m)Tc-MAG(3)-Ga displayed higher accumulation in hepatic tissue, due to the presence of specific receptors in the liver for this carbohydrate. Thus, the use of (99m)Tc-MAG(3)-Ga to assess hepatic function can be considered.

Assuntos

Carboidratos/química , Tecnécio Tc 99m Mertiatida/química , Animais , Carboidratos/síntese química , Carboidratos/farmacocinética , Glicina/análogos & derivados , Glicina/química , Glicina/farmacocinética , Marcação por Isótopo , Fígado/metabolismo , Camundongos , Tecnécio Tc 99m Mertiatida/farmacocinética , Distribuição Tecidual