RESUMO
The mechanisms of the systemic response associated with talc-induced pleurodesis are poorly understood. The aim of this study was to assess the acute inflammatory response and migration of talc of small size particles injected in the pleural space. Rabbits were injected intrapleurally with talc solution containing small or mixed particles and blood and pleural fluid samples were collected after 6, 24 or 48 h and assayed for leukocytes, neutrophils, lactate dehydrogenase, IL-8, VEGF, and TGF-beta. The lungs, spleen, liver and kidneys were assessed to study deposit of talc particles. Both types of talc produced an acute serum inflammatory response, more pronounced in the small particles group. Pleural fluid IL-8 and VEGF levels were higher in the small particle talc group. Correlation between pleural VEFG and TGF-beta levels was observed for both groups. Although talc particles were demonstrated in the organs of both groups, they were more pronounced in the small talc group. In conclusion, intrapleural injection of talc of small size particles produced a more pronounced acute systemic response and a greater deposition in organs than talc of mixed particles.
Assuntos
Derrame Pleural/imunologia , Pleurodese/efeitos adversos , Talco/farmacologia , Reação de Fase Aguda/imunologia , Animais , Biomarcadores/análise , Biomarcadores/sangue , Injeções , Interleucina-8/análise , Interleucina-8/sangue , Rim , L-Lactato Desidrogenase/análise , L-Lactato Desidrogenase/sangue , Contagem de Leucócitos , Leucócitos/imunologia , Fígado , Pulmão , Neutrófilos/imunologia , Tamanho da Partícula , Pleurisia/sangue , Pleurisia/imunologia , Pleurodese/métodos , Coelhos , Baço , Talco/análise , Fator de Crescimento Transformador beta/análise , Fator de Crescimento Transformador beta/sangue , Fator A de Crescimento do Endotélio Vascular/análise , Fator A de Crescimento do Endotélio Vascular/sangueRESUMO
Se analizaron 100 muestras de productos cosméticos de producción nacional (50 de pasta dental y 50 de cajas de talco). Se les realizaron las determinaciones de indicadores de calidad sanitaria (recuento total de microorganismos aerobios mesófilos, de coliformes, de hongos filamentosos y de levaduras viables) y la determinación de microorganismos patógenos. No se aisló en ninguna de las muestras ningún microorganismo patógeno, ni potencialmente patógeno. En relación con los microorganismos indicadores, las muestras de pasta dental se ajustaron a los criterios microbiológicos utilizados como referencia, mientras que algunas muestras de talco, incumplieron en el recuento de hongos filamentosos