RESUMO

The clinical and public health importance of CD4+ T lymphocytopenia without human immunodeficiency virus infection is still unclear. We describe herein two new human immunodeficiency virus-negative patients with low numbers of peripheral CD4+ T cells and opportunistic infections (cerebral toxoplasmosis and tuberculosis plus extrapulmonary histoplasmosis). The low numbers of CD4+ CD29+ memory cells, the high percentage of gamma delta T-cell receptor cells, and the recovery of CD4+ cells after treatment were remarkable.

Assuntos

Subpopulações de Linfócitos T/imunologia , T-Linfocitopenia Idiopática CD4-Positiva/imunologia , Adulto , Antígenos CD4/imunologia , Linfócitos T CD4-Positivos/imunologia , Feminino , Humanos , Integrina beta1/imunologia , Masculino , Pessoa de Meia-Idade , Receptores de Antígenos de Linfócitos T gama-delta/imunologia , T-Linfocitopenia Idiopática CD4-Positiva/terapia