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1.
Environ Sci Pollut Res Int ; 25(24): 24143-24149, 2018 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-29948693

RESUMO

Metsulfuron-methyl is a common active ingredient recommended for use in pre- and post-emergence control of annual grasses and broadleaf weeds in crops, usually applied with mineral oil as adjuvant to enhance its efficiency. Despite the increasing use of this herbicide, there are no information on its ecotoxicity effects to soil fauna. Avoidance and lethality tests were performed with earthworms and collembolans using tropical artificial soil contaminated with formulated products Ally® (600 g L-1 metsulfuron-methyl) and Assist® (756 g L-1 mineral oil) as adjuvant. Lethality test with earthworms showed no difference when tested with or without adjuvant. When Ally® was tested alone, it caused avoidance behavior only at high concentrations (5000 and 10,000 times field predicted dose). However, Assist® addition changed the response of soil invertebrates increasing the avoidance even at field predicted doses. The toxicity of the adjuvant was confirmed in tests exposing collembolans and earthworms to Assist® alone resulting in avoidance behavior. The results clearly show that the addition of mineral oil enhanced the ecotoxicity of metsulfuron-methyl. This study provides an important contribution to the knowledge on the toxicity of metsulfuron-methyl and indicates that adjuvants should be considered in risk assessment of pesticides, considering that under field conditions, these products are applied together.


Assuntos
Artrópodes/efeitos dos fármacos , Sulfonatos de Arila/toxicidade , Ecotoxicologia/métodos , Oligoquetos/efeitos dos fármacos , Poluentes do Solo/toxicidade , Animais , Artrópodes/fisiologia , Sulfonatos de Arila/administração & dosagem , Aprendizagem da Esquiva/efeitos dos fármacos , Herbicidas/administração & dosagem , Herbicidas/toxicidade , Oligoquetos/fisiologia , Poluentes do Solo/administração & dosagem
2.
Curr Drug Deliv ; 8(3): 320-9, 2011 May.
Artigo em Inglês | MEDLINE | ID: mdl-21291382

RESUMO

The archaeolipids (lipids extracted from archaebacterias) are non saponificable molecules that form self sealed mono or bilayers (archaeosomes-ARC). Different to liposomes with bilayers made of conventional glycerophospholipids, the bilayer of ARC posses a higher structural resistance to physico chemical and enzymatic degradation and surface hydrophobicity. In this work we have compared the binding capacity of ARC exclusively made of archaeols containing a minor fraction of sulphoglycophospholipids, with that of liposomes in gel phase on M-like cells in vitro. The biodistribution of the radiopharmaceutical (99m)Tc-DTPA loaded in ARC vs that of liposomes upon oral administration to Wistar rats was also determined. The fluorescence of M-like cells upon 1 and 2h incubation with ARC loaded with the hydrophobic dye Rhodamine-PE (Rh-PE) and the hydrophilic dye pyranine (HPTS) dissolved in the aqueous space, was 4 folds higher than upon incubation with equally labeled liposomes. Besides, 15% of Rh-PE and 13 % of HPTS from ARC and not from liposomes, were found in the bottom wells, a place that is equivalent to the basolateral pocket from M cells. This fact suggested the occurrence of transcytosis of ARC. Finally, 4 h upon oral administration, ARC were responsible for the 22.3 % (3.5 folds higher than liposomes) shuttling of (99m)Tc-DTPA to the blood circulation. This important amount of radioactive marker in blood could be a consequence of an extensive uptake of ARC by M cells in vivo, probably favored by their surface hydrophobicity. Taken together, these results suggested that ARC, proven their adjuvant capacity when administered by parenteral route and high biocompatibility, could be a suitable new type of nanoparticulate material that could be used as adjuvants by the oral route.


Assuntos
Éteres de Glicerila/administração & dosagem , Éteres de Glicerila/química , Pentetato de Tecnécio Tc 99m/administração & dosagem , Pentetato de Tecnécio Tc 99m/química , Administração Oral , Animais , Archaea/química , Sulfonatos de Arila/administração & dosagem , Sulfonatos de Arila/química , Células CACO-2 , Linhagem Celular Tumoral , Técnicas de Cocultura , Portadores de Fármacos/administração & dosagem , Portadores de Fármacos/química , Humanos , Interações Hidrofóbicas e Hidrofílicas , Lipossomos/administração & dosagem , Lipossomos/química , Nanopartículas/administração & dosagem , Nanopartículas/química , Ratos , Ratos Wistar , Rodaminas/administração & dosagem , Rodaminas/química , Pentetato de Tecnécio Tc 99m/sangue , Distribuição Tecidual , Transcitose/fisiologia
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