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1.
Biomedica ; 37(3): 361-367, 2017 Sep 01.
Artigo em Inglês | MEDLINE | ID: mdl-28968013

RESUMO

INTRODUCTION: Chagas disease is a public health problem in Latin America. Even though vector-borne infection is the most important transmission mode for this disease, other modes such as transfusions require evaluation. OBJECTIVE: To describe the prevalence of T. cruzi infection in multitransfused patients. MATERIALS AND METHODS: We detected IgG antibodies against T. cruzi by two immunoassays in samples from multitransfused patients in four hospitals located in Bogotá and Medellín, Colombia. We analyzed the association with known risk factors, and we calculated the odds ratios (OR) with 95% confidence intervals using Stata 11™ statistical software. RESULTS: In total, 479 samples were tested. Overall, T. cruzi antibody prevalence was 1.88% (nine patients). Five were onco-hematological patients, two were hemodialyzed, one had thalassemia, and one had suffered acute blood loss. We found no hemophilia patients. There was no association between known risk factors for transfusion-transmitted infection (such as the number of transfusion events, number of blood units and type of blood component) and the presence of anti-T. cruzi antibodies in this study. Only the hepatitis C virus infection showed a positive association with the presence of anti-T. cruzi antibodies (OR=5.68, 95% CI: 1.36-23.63). CONCLUSIONS: The results of this study showed a low frequency of T. cruzi infection in multitransfused patients, suggesting that the risk of transfusion infection in Colombia is low. Known risk factors for transfusion-related infection were not associated with the presence of anti-T. cruzi antibodies.


Assuntos
Anticorpos Antiprotozoários/sangue , Transfusão de Sangue , Doença de Chagas/transmissão , Reação Transfusional/psicologia , Trypanosoma cruzi/imunologia , Adulto , Doença de Chagas/sangue , Colômbia , Comorbidade , Intervalos de Confiança , Feminino , Hepatite C/epidemiologia , Humanos , Masculino , Pessoa de Meia-Idade , Neoplasias/epidemiologia , Razão de Chances , Prevalência , Diálise Renal , Fatores de Risco , Talassemia/epidemiologia
2.
Biomédica (Bogotá) ; Biomédica (Bogotá);37(3): 361-367, jul.-set. 2017. tab
Artigo em Espanhol | LILACS | ID: biblio-888476

RESUMO

Resumen Introducción. La enfermedad de Chagas es un problema de salud pública en Latinoamérica y, aunque la transmisión vectorial es la más importante, deben evaluarse otras formas de transmisión, como la de las transfusiones. Objetivo. Describir la prevalencia de infección con Trypanosoma cruzi en pacientes sometidos a múltiples transfusiones o multitransfundidos. Materiales y métodos. Se detectaron anticuerpos IgG contra T. cruzi mediante dos inmunoensayos en muestras tomadas de pacientes sometidos a múltiples transfusiones en cuatro hospitales de Bogotá y Medellín, Colombia. Se analizó la asociación de factores de riesgo conocidos y se calcularon las razones de momios (odds ratio, OR) con un intervalo de confianza de 95 % (IC) utilizando el programa Stata 11(tm). Resultados. Se evaluaron 479 muestras. La prevalencia de anticuerpos contra T. cruzifue de 1,88 % (nueve pacientes): cinco pacientes remitidos de oncohematología, dos de hemodiálisis, uno tenía talasemia y uno había sufrido pérdida súbita y abundante de sangre. No se halló ningún paciente con hemofilia que resultara positivo, ni relación de los factores de riesgo de infección asociados con la transfusión de componentes sanguíneos, como el número de transfusiones, la cantidad de unidades de sangre y el tipo de componente, con la presencia de anticuerpos anti-T. cruzi. Solo se encontró relación entre la infección con el virus de la hepatitis C y la presencia de anticuerpos anti-T. cruzi (OR=5,68; IC95% 1,36-23,63). Conclusión. La frecuencia de infección por T. cruzi hallada en este grupo de pacientes sugiere que el riesgo de infección por transfusiones en Colombia es bajo. No se encontró relación entre los factores de riesgo asociados con la transfusión y la presencia de anticuerpos anti-T. cruzi.


Abstract Introduction: Chagas disease is a public health problem in Latin America. Even though vector-borne infection is the most important transmission mode for this disease, other modes such as transfusions require evaluation. Objective: To describe the prevalence of T. cruzi infection in multitransfused patients. Materials and methods: We detected IgG antibodies against T. cruzi by two immunoassays in samples from multitransfused patients in four hospitals located in Bogotá and Medellín, Colombia. We analyzed the association with known risk factors, and we calculated the odds ratios (OR) with 95% confidence intervals using Stata 11(tm) statistical software. Results: In total, 479 samples were tested. Overall, T. cruzi antibody prevalence was 1.88% (nine patients). Five were onco-hematological patients, two were hemodialyzed, one had thalassemia, and one had suffered acute blood loss. We found no hemophilia patients. There was no association between known risk factors for transfusion-transmitted infection (such as the number of transfusion events, number of blood units and type of blood component) and the presence of anti-T. cruzi antibodies in this study. Only the hepatitis C virus infection showed a positive association with the presence of anti-T. cruzi antibodies (OR=5.68, 95% CI: 1.36-23.63). Conclusions: The results of this study showed a low frequency of T. cruzi infection in multitransfused patients, suggesting that the risk of transfusion infection in Colombia is low. Known risk factors for transfusion-related infection were not associated with the presence of anti-T. cruzi antibodies.


Assuntos
Adulto , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Trypanosoma cruzi/imunologia , Transfusão de Sangue , Anticorpos Antiprotozoários/sangue , Doença de Chagas/transmissão , Reação Transfusional/psicologia , Talassemia/epidemiologia , Comorbidade , Intervalos de Confiança , Razão de Chances , Prevalência , Fatores de Risco , Diálise Renal , Hepatite C/epidemiologia , Doença de Chagas/sangue , Colômbia , Neoplasias/epidemiologia
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