RESUMO
Mast cells (MCs) display a diversity of roles that may contribute to the stromal microenvironment alterations during tumor progression. The aim of this study was to investigate MC populations expressing tryptase and c-kit in lip squamous cell carcinoma (lip SCC) (n=37), actinic cheilitis (AC) (n=15) and normal lip mucosa (control) (n=6), as well as their relationship with microscopic parameters (collagen degeneration, elastin changes, angiogenesis and proliferative index). Tryptase, c-kit, CD31 and Ki-67 expressions were analyzed by means of immunohistochemistry and collagen and elastic fibers were visualized with Picrosirus and Verhoeff's stain, respectively. The numbers of tryptase+ MC were significantly higher in lip SCC when compared with control (P=0.01), while a similar density of these cells was observed in AC and lip SCC (P=0.09). The density of c-kit+ MC was similar in all groups examined (P=0.65). MC migration (c-kit+/Tryptase+ relationship) was 69% in lip SCC, 60% in AC and 100% in control. The number of CD31+ blood vessels was significantly higher in the lip SCC when compared with control and AC (P<0.01). The increase of MCs and angiogenesis in lip SCC may reflect an important modification in the tumor microenvironment during squamous photo-carcinogenesis.
Assuntos
Carcinoma de Células Escamosas/patologia , Movimento Celular , Queilite/patologia , Neoplasias Labiais/patologia , Mastócitos/enzimologia , Mastócitos/patologia , Adulto , Fatores Etários , Idoso , Idoso de 80 Anos ou mais , Carcinoma de Células Escamosas/irrigação sanguínea , Carcinoma de Células Escamosas/fisiopatologia , Queilite/fisiopatologia , Colágeno/metabolismo , Elastina/metabolismo , Matriz Extracelular/metabolismo , Matriz Extracelular/patologia , Feminino , Humanos , Antígeno Ki-67/metabolismo , Neoplasias Labiais/irrigação sanguínea , Neoplasias Labiais/fisiopatologia , Masculino , Pessoa de Meia-Idade , Mucosa Bucal/irrigação sanguínea , Mucosa Bucal/patologia , Mucosa Bucal/fisiopatologia , Neovascularização Patológica , Molécula-1 de Adesão Celular Endotelial a Plaquetas/metabolismo , Proteínas Proto-Oncogênicas c-kit/metabolismo , Triptases/metabolismo , Raios UltravioletaRESUMO
Todos los pacientes presentaron por lo menos una manifestación dermatológica. Los cambios de coloración fueron los más frecuentes. No ha sido reportada la hiperpigmentación de salientes óseas que observamos en el 38 por ciento de los casos. En el 76 por ciento se encontró xerosis, infecciones en el 66 por ciento, dermopatía diabética en 32 por ciento, prurito en 50 por ciento, queilitis en 17.52 por ciento, uñas mitad y mitad en 28 por ciento y sólo un caso de foliculitis urémica