RESUMO
Nonalcoholic fatty liver disease (NAFLD) is associated with multiple factors such as obesity, insulin resistance, and oxidative stress. Nopal, a cactus plant widely consumed in the Mexican diet, is considered a functional food because of its antioxidant activity and ability to improve biomarkers of metabolic syndrome. The aim of this study was to assess the effect of nopal consumption on the development of hepatic steatosis and hepatic oxidative stress and on the regulation of genes involved in hepatic lipid metabolism. Obese Zucker (fa/fa) rats were fed a control diet or a diet containing 4% nopal for 7 wk. Rats fed the nopal-containing diet had â¼50% lower hepatic TG than the control group as well as a reduction in hepatomegaly and biomarkers of hepatocyte injury such as alanine and aspartate aminotransferases. Attenuation of hepatic steatosis by nopal consumption was accompanied by a higher serum concentration of adiponectin and a greater abundance of mRNA for genes involved in lipid oxidation and lipid export and production of carnitine palmitoyltransferase-1 and microsomal TG transfer proteins in liver. Hepatic reactive oxygen species and lipid peroxidation biomarkers were significantly lower in rats fed nopal compared with the control rats. Furthermore, rats fed the nopal diet had a lower postprandial serum insulin concentration and a greater liver phosphorylated protein kinase B (pAKT):AKT ratio in the postprandial state. This study suggests that nopal consumption attenuates hepatic steatosis by increasing fatty acid oxidation and VLDL synthesis, decreasing oxidative stress, and improving liver insulin signaling in obese Zucker (fa/fa) rats.
Assuntos
Ração Animal , Fígado Gorduroso/dietoterapia , Obesidade/dietoterapia , Opuntia , Estresse Oxidativo , Adiponectina/sangue , Adiponectina/metabolismo , Animais , Dieta , Ingestão de Alimentos , Regulação da Expressão Gênica , Insulina/metabolismo , Metabolismo dos Lipídeos , Proteinose Lipoide de Urbach e Wiethe/metabolismo , Fígado/metabolismo , Masculino , Ratos , Ratos Zucker , Transdução de Sinais , Aumento de PesoRESUMO
The cutaneous deposition disorders are a group of unrelated conditions characterized by the presence of either endogenous or exogenous substances within the dermis or the subcutis. Part I of this two-part series will focus on metabolic processes involved in the endogenous deposition in the various forms of amyloidosis, porphyria, colloid milium, and lipoid proteinosis. We will also review the clinical, histologic, biochemical, and ultrastructural findings relevant to each disorder. Basic mechanisms of pathogenesis, diagnostic modalities, and treatment options are also discussed.
Assuntos
Humanos , Amiloidose/complicações , Amiloidose/diagnóstico , Amiloidose/etiologia , Amiloidose/metabolismo , Amiloidose/patologia , Amiloidose/terapia , Dermatopatias Metabólicas/diagnóstico , Dermatopatias Metabólicas/etiologia , Dermatopatias Metabólicas/metabolismo , Dermatopatias Metabólicas/patologia , Dermatopatias Metabólicas/terapia , Dermatopatias/diagnóstico , Dermatopatias/etiologia , Dermatopatias/metabolismo , Dermatopatias/patologia , Dermatopatias/terapia , Lipidoses/diagnóstico , Lipidoses/etiologia , Lipidoses/metabolismo , Lipidoses/patologia , Lipidoses/terapia , Pele/metabolismo , Pele/patologia , Porfirias/diagnóstico , Porfirias/etiologia , Porfirias/metabolismo , Porfirias/patologia , Porfirias/terapia , Proteinose Lipoide de Urbach e Wiethe/diagnóstico , Proteinose Lipoide de Urbach e Wiethe/etiologia , Proteinose Lipoide de Urbach e Wiethe/metabolismo , Proteinose Lipoide de Urbach e Wiethe/patologia , Proteinose Lipoide de Urbach e Wiethe/terapiaRESUMO
We describe a 65-year-old-man who presented with acute gastrointestinal bleeding secondary to massive submucosal deposits of hyaline material in the small bowel. The histochemical and ultrastructural features of the hyaline substance were typical of lipoid proteinosis, a rare cutaneous disorder in which, to our knowledge, symptomatic compromise of internal organs has not been described previously. The patient was later found to have mild but characteristic mucocutaneous lesions of lipoid proteinosis, as well as asymptomatic deposits in other gastrointestinal sites. Our case documents that severe visceral involvement may occur in lipoid proteinosis, even in previously undiagnosed patients with mild cutaneous manifestations of the disease.