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Eur J Pharm Sci ; 78: 79-89, 2015 Oct 12.
Artigo em Inglês | MEDLINE | ID: mdl-26159738

RESUMO

Trans-resveratrol (RES) is used in cosmetic formulations and beta-carotene (BTC) is a classical sunscreen antioxidant, but their photostability in sunscreens, a property directly correlated to performance and safety has not been addressed in the literature. This paper reports the assessment of RES and/or BTC influence on the photostability of five UV-filters (octyl methoxycinnamate - OMC, avobenzone -AVO, octocrylene - OCT, bemotrizinole - BMZ, octyltriazone - OTZ) in three different combinations after UVA exposure followed by the identification of degradation products and the assessment of photoreactivity. The evaluation of sunscreen photostability was performed by HPLC and spectrophotometric analysis, and degradation products were identified by GC-MS analysis. Components RES, BTC, OMC and AVO were significantly degraded after UV exposure (reduction of around 16% in recovery). According to HPLC analysis, all formulations presented similar photostability profiles. Eleven degradation products were identified in GC-MS analysis, among them products of RES, BTC, OMC and AVO photodegradation. All evaluated formulations were considered photoreactive, as well as the isolated compounds RES and AVO. Considering HPLC, spectrophotometric and GC-MS results, it is suggested that formulations containing BMZ were considered the most photostable. The combination RES+BTC in a sunscreen improved the photostability of AVO. The benefits of using a combination of antioxidants in sunscreens was demonstrated by showing that using RES+BTC+studied UV-filters led to more photostable formulations, which in turn implies in better safety and efficacy.


Assuntos
Estilbenos/efeitos da radiação , Protetores Solares/efeitos da radiação , Raios Ultravioleta , beta Caroteno/efeitos da radiação , Acrilatos/efeitos da radiação , Benzoatos/efeitos da radiação , Cromatografia Líquida de Alta Pressão , Cinamatos/efeitos da radiação , Estabilidade de Medicamentos , Cromatografia Gasosa-Espectrometria de Massas , Fenóis/efeitos da radiação , Fotólise , Propiofenonas/efeitos da radiação , Resveratrol , Oxigênio Singlete/química , Espectrofotometria Ultravioleta , Superóxidos/química , Triazinas/efeitos da radiação
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