RESUMO

Recent data have shown an association between polyunsaturated fatty acid and depression. This study examined the effect of the supplementation with n-6 fatty acid on the behavior of rats treated with imipramine and submitted to the Forced Swimming Test (FST). Non-supplemented imipramine-treated rats presented a significant reduction of immobility time in the FST whereas n-6 fatty acid-supplemented rats showed a significantly higher immobility time. Imipramine significantly increased norepinephrine plasma concentrations in the two groups. These results show that the diet supplemented with n-6 fatty acid altered the behavior of the animals in the FST, inhibiting the imipramine effect.

Assuntos

Antidepressivos Tricíclicos/farmacologia , Depressão/tratamento farmacológico , Ácidos Graxos Ômega-6/farmacologia , Imipramina/farmacologia , Animais , Peso Corporal/efeitos dos fármacos , Catecolaminas/sangue , Cromatografia Líquida de Alta Pressão , Depressão/psicologia , Dieta , Eletroquímica , Masculino , Óleos de Plantas/química , Primula/química , Ratos , Ratos Wistar , Serotonina/sangue , Natação/psicologia