RESUMO
Oral poliovirus vaccine (OPV) developed by A. Sabin has been effectively used to control poliomyelitis in Brazil, and the last case with the isolation of a wild poliovirus strain occurred in March 1989. Although the vaccine controlled the circulation of wild strains and poliomyelitis cases associated with these strains were not detected during the last eight years, rare cases classified as vaccine-associated paralytic poliomyelitis (VAPP) have been detected. Molecular characterization studies of poliovirus strains isolated from VAPP cases and from healthy contacts have confirmed that the isolates are derived from the Sabin vaccine strains and also detected genomic modifications known or suspected to increase neurovirulence such as mutations and recombination. The molecular characterization of polioviruses isolated during the last eight years from paralysis cases classified as Guillain-Barré (GBS) syndrome and transverse myelitis (TM), and from facial paralysis (FP) cases also confirmed the vaccine origin of the strains and demonstrated mutations known to increase neurovirulence. Analysis of the epidemiologic data of these GBS, TM and FP cases demonstrated that in most of them the last OPV dose was given months or years before the onset of the disease and the isolation of the polioviruses. The temporal association between the isolation of these strains and the GBS, TM and FP suggested that the Sabin vaccine-derived poliovirus strains could also rarely trigger the diseases.
Assuntos
Paralisia Facial/virologia , Mielite Transversa/virologia , Poliomielite/prevenção & controle , Vacina Antipólio Oral/efeitos adversos , Polirradiculoneuropatia/virologia , Brasil , Paralisia Facial/genética , Humanos , Mielite Transversa/genética , Poliovirus/genética , Polirradiculoneuropatia/genéticaRESUMO
Oral poliovirus vaccine (OPV) developed by A. Sabin has been effectively used to control poliomyelitis in Brazil, and the last case with the isolation of a wild poliovirus strain occourred in March 1989. Although the vaccine controlled the circulation ...
Assuntos
Humanos , Paralisia Facial/genética , Paralisia Facial/virologia , Mielite Transversa/genética , Mielite Transversa/virologia , Poliomielite/prevenção & controle , Vacina Antipólio Oral/efeitos adversos , Poliovirus/genética , Polirradiculoneuropatia/genética , Polirradiculoneuropatia/virologia , Brasil , Reação em Cadeia da PolimeraseAssuntos
Infecções por Campylobacter/complicações , Enterite/complicações , Polirradiculoneuropatia/etiologia , Polirradiculoneuropatia/genética , Infecções por Campylobacter/microbiologia , Campylobacter jejuni/isolamento & purificação , Pré-Escolar , Enterite/microbiologia , Feminino , Humanos , Lactente , SorotipagemRESUMO
The distribution of HLA-DR antigens was investigated in 38 Mexican Mestizo patients with Guillain-Barré syndrome (GBS) and in 100 healthy controls belonging to the same population. IgG, IgM, IgA, CH50, C3, C4 and the number of T and B lymphocytes were also evaluated in the patients. Only DR3 was significantly increased in the patients (Yates' chi 2 = 9.943, Pc = 0.014) and the relative risk for developing the disease was 3.49. These findings support the hypothesis that DR3 or a closely linked Ir gene may play some role in the susceptibility to GBS.