RESUMO
INTRODUCTION: Plantar warts often are refractory to any treatment and can last for decades in adults. Recalcitrant warts are defined as those that have persisted for more than two years, or after at least two treatment modalities. METHODS: A total of 15 consecutive patients with recalcitrant plantar warts were included in this preliminary study. The treatment consisted of applying one to two sessions that comprised compounding 1% cantharidin, 5% of podophyllotoxin, and 30% salicylic acid (CPS), with an interval between applications of four weeks. RESULTS: With treatment and subsequent follow-up for six months, there was complete eradication of lesions in 15 patients, eight (53.3%) required a single application of the solution, and seven (46.7%) two applications, with no side effects. Patient satisfaction related to treatment was measured by a visual analog scale (VAS) of 10 cm in length, with an average score 9.73 ± 0.46, and all said they would proceed with the treatment again if necessary. CONCLUSIONS: Topical treatment by compounding is safe, effective, and a promising therapeutic modality when applied in recalcitrant plantar warts.
Assuntos
Cantaridina/uso terapêutico , Podofilotoxina/uso terapêutico , Ácido Salicílico/uso terapêutico , Verrugas/tratamento farmacológico , Administração Cutânea , Adolescente , Adulto , Cantaridina/administração & dosagem , Cantaridina/efeitos adversos , Combinação de Medicamentos , Composição de Medicamentos , Feminino , Seguimentos , Humanos , Ceratolíticos/administração & dosagem , Ceratolíticos/efeitos adversos , Ceratolíticos/uso terapêutico , Masculino , Satisfação do Paciente , Podofilotoxina/administração & dosagem , Podofilotoxina/efeitos adversos , Ácido Salicílico/administração & dosagem , Ácido Salicílico/efeitos adversos , Resultado do Tratamento , Verrugas/patologia , Adulto JovemRESUMO
In the present study we have utilized the Allium cepa root tip meristem model to evaluate the cytotoxic and anti-mitotic activities of latex of Calotropis procera (DL) and podophyllotoxin. Standard cyto-toxic drug cyclophosphamide and non-cytotoxic drugs cyproheptadine and aspirin served as controls. Like cyclophosphamide, both DL and podophyllotoxin significantly inhibited the growth of roots and mitotic activity in a dose-dependent manner. However, podophyllotoxin was more potent in this regard and produced root decay. Cyproheptadine and aspirin, on the other hand, showed a marginal effect on the root growth and mitotic activity at much higher concentrations
Assuntos
Calotropis/química , Cebolas/citologia , Cebolas/crescimento & desenvolvimento , Cebolas , Citotoxinas/efeitos adversos , Citotoxinas/farmacologia , Látex/efeitos adversos , Látex/farmacologia , Podofilotoxina/efeitos adversos , Podofilotoxina/farmacologia , Ciclofosfamida/efeitos adversos , Meristema/crescimento & desenvolvimento , Meristema/efeitos adversos , MitoseRESUMO
In the present study we have utilized the Allium cepa root tip meristem model to evaluate the cytotoxic and anti-mitotic activities of latex of Calotropis procera (DL) and podophyllotoxin. Standard cyto-toxic drug cyclophosphamide and non-cytotoxic drugs cyproheptadine and aspirin served as controls. Like cyclophosphamide, both DL and podophyllotoxin significantly inhibited the growth of roots and mitotic activity in a dose-dependent manner. However, podophyllotoxin was more potent in this regard and produced root decay. Cyproheptadine and aspirin, on the other hand, showed a marginal effect on the root growth and mitotic activity at much higher concentrations(AU)
Assuntos
Citotoxinas/efeitos adversos , Citotoxinas/farmacologia , Látex/efeitos adversos , Látex/farmacologia , Calotropis/química , Podofilotoxina/efeitos adversos , Podofilotoxina/farmacologia , Cebolas/citologia , Cebolas/efeitos dos fármacos , Cebolas/crescimento & desenvolvimento , Ciclofosfamida/efeitos adversos , Meristema/efeitos adversos , Meristema/crescimento & desenvolvimento , Mitose/efeitos dos fármacosRESUMO
In the present study we have utilized the Allium cepa root tip meristem model to evaluate the cytotoxic and anti-mitotic activities of latex of Calotropis procera (DL) and podophyllotoxin. Standard cyto-toxic drug cyclophosphamide and non-cytotoxic drugs cyproheptadine and aspirin served as controls. Like cyclophosphamide, both DL and podophyllotoxin significantly inhibited the growth of roots and mitotic activity in a dose-dependent manner. However, podophyllotoxin was more potent in this regard and produced root decay. Cyproheptadine and aspirin, on the other hand, showed a marginal effect on the root growth and mitotic activity at much higher concentrations(AU)