RESUMO

Sydenham's chorea (SC) is thought to result from the action of streptococcus-induced antibodies that cross react with basal ganglia antigens. Much less is known, however, about the involvement of cellular mechanisms in its pathogenesis. Since chemokines seem to play a role in several CNS inflammatory disorders, we sought to investigate the chemokine profile of patients with SC. Increased serum levels of CXCL9, formerly monokine induced by interferon-gamma (Mig), and CXCL10, formerly interferon-gamma-inducible protein of 10 kDa (IP-10) were demonstrated in acute SC patients, suggesting that a particular group of chemokines may be involved in SC pathogenesis.

Assuntos

Quimiocinas CXC/sangue , Coreia/imunologia , Peptídeos e Proteínas de Sinalização Intercelular/sangue , Doença Aguda , Adolescente , Adulto , Quimiocina CXCL10 , Quimiocina CXCL9 , Quimiocinas CXC/líquido cefalorraquidiano , Criança , Coreia/sangue , Coreia/líquido cefalorraquidiano , Feminino , Humanos , Mediadores da Inflamação/sangue , Mediadores da Inflamação/líquido cefalorraquidiano , Peptídeos e Proteínas de Sinalização Intercelular/líquido cefalorraquidiano , Masculino , Pessoa de Meia-Idade , Regulação para Cima/imunologia