RESUMO
Tropical spastic paraparesis (TSP) is a chronic myelopathy that was initially recogized in tropical countries in the nineteen century. For several decades no aetiological agent was identified until in 1985 when IgG antibodies to human T-cell lymphotropic virus Type 1 (HTLV-I) were found in serum and cerebrospinal fluid of patients from Jamaica, Columbia and Martinique. Soon after, a similar clinical syndrome named HTLV-I associated myelopathy (HAM) was described from the temperate region of Kyushu in Japan. In 988 the name TSP/HAM was introduced to include all HTLV-I positive patients with the clinical criteria of this chronic myelopathy. No major changes have been noted in the clinical features of these patients over the years but with the increased numbers of patients studied many more HTLV-I associated syndromes have been identified. Non HTLV-I positive TSP is still reported in several countries and the conclusion must be that this chronic spastic paraparesis has diverse aetiologies. (AU)
Assuntos
Adolescente , Adulto , Feminino , História do Século XX , Paraparesia Espástica Tropical/história , Paraparesia Espástica Tropical/diagnóstico , Vírus Linfotrópico T Tipo 1 Humano/isolamento & purificação , JamaicaRESUMO
The tropical spastic paraparesis (TSP) is a chronic myelopathy, predominant in the tropics, recently known to be of retroviral origin (HTLV-I). This paper aims at delineating the clinico-etiological evolution of this entity. The historical analysis of it showed that the TSP has had, along decades, many different denominations and the discovery of the retroviral origin for some of them has stimulated new paths of research and epidemiological interest in the tropics and Brazil.
Assuntos
Paraparesia Espástica Tropical/história , Brasil , História do Século XIX , História do Século XX , Humanos , Paraparesia Espástica Tropical/microbiologiaRESUMO
A paraparesia espástica tropical (PET)é mielopatia crônica, observada predominantemente nos trópicos recentemente descoberta ser de origem retroviral (HTLV-I). O objetivo deste estudo foi delinear a evoluçäo histórica de sua descriçäo, denominaçöes e referências etiológicas. A análise histórica revelou que essa condiçäo teve diferentes denominaçöes e a descoberta de sua etiologia retroviral em parte dos casos abriu diversas linhas de investigaçöes e interesse epidemiológico, nos trópicos e no Brasil
Assuntos
Humanos , Paraparesia Espástica Tropical/história , Brasil , Paraparesia Espástica Tropical/etiologiaRESUMO
Faz-se uma revisäo do problema das neuropatias associadas ao protovírus T-linfotrópicos humano (HTLV-I)- NAH- sob o ponto de vista histórico
Assuntos
Vírus Linfotrópico T Tipo 1 Humano , Paraparesia Espástica Tropical/história , Doenças da Medula Espinal/etiologia , Paraparesia Espástica Tropical/etiologiaRESUMO
An abridged review of the current status of chronic endemic neuropathy associated with human lymphotropic virus type I is presented. Tropical and non trpopical spastic paraparesis are associated with HTL V -I antibodies and the virus has been isolated from the blood and spinal fluid of patients, and probably they are a similar process. The case of a 57 year old black female from St. Croix, USVI, with a six year history of progressive spastic paraparesis, sphincter disturbances and subjective sensory complaints is described. Antibodies to HTL V-I were detected by the Elisa and confirmed by Western blot. The patient was treated with Zidovudine 200 mgrs three times a day for six weeks. At the end of this period she was able to walk without assistance, dance, jump and squat. Spasticity, sensory and sphinter disturbances disappeared