RESUMO
Vocal cord paralysis after administration of the chemotherapeutic agent vincristine is a rare occurrence. Most occurrences are bilateral. Of the 24 cases referenced in this article, 19 are children. In all the reported cases, symptoms have occurred after multiple doses of vincristine have been administered. The authors report a case of a 39-year-old woman with unilateral vocal cord motion impairment occurring 3 days after the administration of the first dose of vincristine. This is the first case of vocal cord motion impairment reported after the administration of only 1 dose of this drug.
Assuntos
Antineoplásicos Fitogênicos/efeitos adversos , Neoplasias Ósseas/tratamento farmacológico , Sarcoma de Ewing/tratamento farmacológico , Vincristina/efeitos adversos , Paralisia das Pregas Vocais/induzido quimicamente , Adulto , Feminino , HumanosRESUMO
Life-threatening organophosphate-induced delayed polyneuropathy with transient bilateral vocal cord paralysis occurred in a 3-year-old child. Recovery was slow after prolonged ventilatory support. Patients who recover from serious organophosphate intoxications should be closely monitored for the development of organophosphate-induced delayed polyneuropathy.