RESUMO
The aim of the current report was to describe 3 cases of malignant carotid body tumor (CBT) and to review the literature. My clinical records of 87 CBTs in 81 patients (6 bilateral) were reviewed, 79 of which were operated on. Three malignant cases were found. The first was in a 40-year-old man who presented with pulmonary metastases 6 years after resection of a CBT. He was treated with chemotherapy and interferon, but died with disseminated disease 2 years later. The second case was in a 56-year-old woman who had a 5-cm, fixed, hard mass in the upper aspect of the neck and a paralysis of the left vocal cord. This lesion was completely resected, and a shunt and reconstruction with a saphenous vein graft were performed. Pathology revealed a malignant chemodectoma with invasion to 2 of the 5 lymph nodes removed. Radiotherapy (50 Gy) was given after the operation. She is well and free of disease 68 months after the resection. The third case was in a 61-year-old woman who presented with an 8-cm nontender, hard, immobile mass in the left upper neck that displaced the left wall of the oropharynx toward the midline. A carotid arteriogram showed a CBT. On computed tomography, the tumor extended to the infratemporal fossa with no bone involvement. The lesion was embolized with a 40% reduction in vascularity. At surgical exploration, the tumor involved the sternocleidomastoid muscle and the lymph nodes at levels II and III, and the internal carotid artery could not be dissected free at the skull base, so only a partial resection was performed. This patient was lost to follow-up. These 3 cases are in agreement with the literature. Locoregional control is usually obtained with complete primary tumor resection and lymphadenectomy and eventual radiotherapy. Surgery with radiotherapy seems to be effective for isolated metastases. Current multidisciplinary treatments have been unsuccessful in controlling disseminated disease.
Assuntos
Tumor do Corpo Carotídeo , Paraganglioma Extrassuprarrenal , Adulto , Tumor do Corpo Carotídeo/diagnóstico , Tumor do Corpo Carotídeo/patologia , Tumor do Corpo Carotídeo/terapia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Paraganglioma Extrassuprarrenal/diagnóstico , Paraganglioma Extrassuprarrenal/patologia , Paraganglioma Extrassuprarrenal/secundário , Paraganglioma Extrassuprarrenal/terapiaAssuntos
Humanos , Masculino , Feminino , Adolescente , Adulto , Pessoa de Meia-Idade , Neoplasias Brônquicas/classificação , Neoplasias Brônquicas/complicações , Neoplasias Brônquicas/diagnóstico , Neoplasias Brônquicas/patologia , Neoplasias Brônquicas/terapia , Broncoscopia , Broncoscopia/normas , Neoplasias Pulmonares/classificação , Neoplasias Pulmonares/diagnóstico , Neoplasias Pulmonares/terapia , Fístula Arteriovenosa/diagnóstico , Fístula Arteriovenosa/etiologia , Fístula Arteriovenosa/história , Fístula Arteriovenosa/terapia , Paraganglioma Extrassuprarrenal/diagnóstico , Paraganglioma Extrassuprarrenal/história , Paraganglioma Extrassuprarrenal/patologia , Paraganglioma Extrassuprarrenal/terapia , Hamartoma/diagnóstico , Hamartoma/terapiaRESUMO
Se presentan tres casos de tumores originados en los paraganglios no cromafines localizados en diferentes áreas de la cabeza y el cuello. Se revisan las principales características de estos tumores así como los criterios actuales para su diagnóstico y tratamiento, ya que en el pasado el sistema de paraganglios no cromafines, fue causa de confusión en lo referente a su origen embriológico, su papel fisiológico y la nomenclatura empleada