RESUMO
Abstract: We report a 42-year-old cocaine addicted female patient referred for evaluation of hard palate ulceration resulting in oro-sinus communication with difficulties in swallowing and phonation, an rhino-sinusitis. Acrylic and removable silicone prosthesis was prescribed to relieve severe functional disorders. It is essential that the patient permanently abandons cocaine use to perform surgical reconstruction.
Assuntos
Humanos , Feminino , Adulto , Fístula Bucal/diagnóstico , Fístula Bucal/induzido quimicamente , Transtornos Relacionados ao Uso de Cocaína/complicações , Palato Duro/efeitos dos fármacos , Perfuração do Septo Nasal/diagnóstico , Perfuração do Septo Nasal/induzido quimicamente , Obturadores Palatinos , Tomografia Computadorizada por Raios X , Fístula Bucal/terapia , Cocaína/efeitos adversos , Palato Duro/diagnóstico por imagem , Perfuração do Septo Nasal/terapiaRESUMO
We report a 42-year-old cocaine addicted female patient referred for evaluation of hard palate ulceration resulting in oro-sinus communication with difficulties in swallowing and phonation, an rhino-sinusitis. Acrylic and removable silicone prosthesis was prescribed to relieve severe functional disorders. It is essential that the patient permanently abandons cocaine use to perform surgical reconstruction.
Assuntos
Transtornos Relacionados ao Uso de Cocaína/complicações , Perfuração do Septo Nasal/induzido quimicamente , Perfuração do Septo Nasal/diagnóstico , Fístula Bucal/induzido quimicamente , Fístula Bucal/diagnóstico , Palato Duro/efeitos dos fármacos , Adulto , Cocaína/efeitos adversos , Feminino , Humanos , Perfuração do Septo Nasal/terapia , Fístula Bucal/terapia , Obturadores Palatinos , Palato Duro/diagnóstico por imagem , Tomografia Computadorizada por Raios XRESUMO
This article reports a rare case of extensive palatal pigmentation secondary to long-term chloroquine treatment. Chloroquine was originally used as an antimalarial agent, but it is now widely used as an adjunct in the treatment of autoimmune diseases. Adverse effects of chloroquine usually include skin changes such as bullous pemphigoid, exacerbation of psoriasis, and pigmentation of the skin and mucous membranes as well as retinopathy, gastrointestinal alterations, and neuromuscular disorders. Extensive oral pigmentation is an uncommon feature of an adverse drug effect, and diagnosis should be based on clinicopathological findings.
Assuntos
Antirreumáticos/efeitos adversos , Cloroquina/efeitos adversos , Hiperpigmentação/induzido quimicamente , Doenças Maxilares/induzido quimicamente , Palato Duro/efeitos dos fármacos , Artrite Reumatoide/tratamento farmacológico , Tecido Conjuntivo/patologia , Epitélio/patologia , Feminino , Humanos , Hiperpigmentação/patologia , Ferro/análise , Doenças Maxilares/patologia , Pessoa de Meia-Idade , Palato Duro/patologiaRESUMO
Pigmentation of the oral mucosa can indicate a wide range of lesions or conditions. Some drugs are associated with pigmented lesions of oral cavity. Imatinib mesylate (Gleevec(®)) is a protein inhibitor used in the management of several hematological malignancies associated with dermatological side effects, like hyperpigmentation. We report the case of a 38-year-old male post-HSCT patient who had been using imatinib mesylate for over 5 years and presented with blue pigmentation on the hard palate, the left side of the nose and both ear lobes. The differential diagnosis of hyperpigmented lesions in the oral mucosa is also presented.
Assuntos
Antineoplásicos/efeitos adversos , Transplante de Células-Tronco Hematopoéticas , Hiperpigmentação/induzido quimicamente , Doenças Maxilares/induzido quimicamente , Palato Duro/efeitos dos fármacos , Piperazinas/efeitos adversos , Pirimidinas/efeitos adversos , Adulto , Benzamidas , Otopatias/induzido quimicamente , Orelha Externa/efeitos dos fármacos , Dermatoses Faciais/induzido quimicamente , Humanos , Mesilato de Imatinib , Masculino , Segunda Neoplasia Primária/patologia , Neurofibromatose 1/patologia , Doenças Nasais/induzido quimicamente , Leucemia-Linfoma Linfoblástico de Células Precursoras/tratamento farmacológico , Leucemia-Linfoma Linfoblástico de Células Precursoras/cirurgia , Proteínas Tirosina Quinases/antagonistas & inibidores , Condicionamento de Tecido Mole OralRESUMO
The side-effects of many drugs manifest in the oral mucosa. The anti-malarial agent chloroquine diphosphate, which is also used to treat immunological, dermatological, and rheumatological disorders, usually causes pigmentary changes in the oral mucosa. This report presents a case of palate pigmentation related to the prolonged use of chloroquine diphosphate caused by the deposition of drug metabolites in the mucosa. Healthcare professionals must be aware of these drugs and their adverse effects in order to make the correct diagnosis, decide on the optimal treatment for the condition, or refer the patient to an appropriate specialist.
Assuntos
Antimaláricos/efeitos adversos , Cloroquina/efeitos adversos , Hiperpigmentação/induzido quimicamente , Mucosa Bucal/efeitos dos fármacos , Palato Duro/efeitos dos fármacos , Feminino , Humanos , Pessoa de Meia-IdadeRESUMO
This study was undertaken to examine the normal and abnormal epithelial alterations of secondary palate in rats. Control and dexamethasone-treated embryos and fetuses of Wistar rats were evaluated by macroscopic and scanning electron microscopic analysis prior to, during, and after fusion of palatal processes. Normal alterations of the surface topography included growth and disorganization of medial edge epithelial cells followed by fusion and posterior migration to both the oral and nasal aspects of the palate. No evidence of epithelial cell death or transformation was observed. Dexamethasone-treated fetuses showed epithelial cells increased in size with a large amount of desquamation, followed by deposition of a disorganized cell layer with keratin-like characteristics. This allowed no fusion of palatal processes.